Recovery of hibernating myocardium: what is the role of surgical revascularization?
Recovery of hibernating myocardium: what is the role of surgical revascularization?
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冬眠心肌的恢复：血运重建手术的作用是什么？
DOI：
10.1111/jocs.12477
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发表时间：
2015
影响因子：
1.6
通讯作者：
Kelly,RosemaryF
中科院分区：
文献类型：
--
作者：
Holley,ChristopherT;Long,EricK;Lindsey,MeganE;McFalls,EdwardO;Kelly,RosemaryF
心肌对慢性缺血的反应代表了一系列适应，随着时间的推移，产生了抗应激表型。一种这样的适应，冬眠心肌（HM），具有增加的抗氧化能力，可防止缺血诱导的氧化应激。研究表明，单靠血运重建可能无法完全恢复心脏功能，因此需要靶向治疗来促进血运重建后的先天愈合过程。在我们的综述中，我们讨论了目前对HM的理解和手术血运重建后的恢复过程，重点是HM的动物模型，以了解对人类患者的影响。doi：10.1111/jocs.12477（J Card Surg 2015;30：224-231）
Myocardial responses to chronic ischemia represent a continuum of adaptations resulting, over time, in a stress‐resistant phenotype. One such adaptation, hibernating myocardium (HM), has increased antioxidant capacity that protects against ischemia‐induced oxidative stress. Studies have suggested that revascularization alone may not fully restore cardiac function, highlighting the need for targeted therapies to serve as adjuncts to the innate healing process following revascularization. In our review, we discuss current understanding of HM and the recovery process following surgical revascularization, focusing on animal models of HM to understand implications for human patients. doi: 10.1111/jocs.12477(J Card Surg 2015;30:224–231)