Sensorineural hearing loss as evidenced by the auditory brainstem response following prenatal cocaine exposure in the Long-Evans rat.
Sensorineural hearing loss as evidenced by the auditory brainstem response following prenatal cocaine exposure in the Long-Evans rat.
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DOI：
10.1002/tera.1420430610
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发表时间：
1991-06
期刊：
影响因子：
--
通讯作者：
M. Church;G. Overbeck
中科院分区：
文献类型：
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作者：
M. Church;G. Overbeck
产前接触可卡因与各种不良神经影响有关。最近的三项研究发现，产前可卡因暴露与异常的听觉电生理学有关，这表明听觉信息的异常处理。本研究采用听性脑干反应（ABR）技术，在Long-Evans大鼠模型上评价了产前可卡因暴露对听力的影响。我们报告，产前可卡因暴露可导致ABR阈值升高和潜伏期-强度曲线符合招募型感音神经性听力损失。
Prenatal cocaine exposure has been associated with a variety of adverse neurological effects. Three recent studies found evidence that prenatal cocaine exposure is associated with abnormal auditory electrophysiology, suggesting abnormal processing of auditory information. The present study used the auditory brainstem response to evaluate the effects of prenatal cocaine exposure on hearing in an animal model (Long-Evans rat). We report that prenatal cocaine exposure can cause elevated ABR thresholds and latency-intensity curves consistent with a recruitment-type sensorineural hearing loss.