Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: Do children of all ages respond equally?
Trivalent inactivated influenza vaccine (TIV) immunogenicity in children 6 through 23 months of age: Do children of all ages respond equally?
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DOI：
10.1016/j.vaccine.2010.04.058
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发表时间：
2010-06-17
期刊：
影响因子：
5.5
通讯作者：
Englund, Janet A.
中科院分区：
文献类型：
--
作者：
Walter, Emmanuel B.;Rajagopal, Shilpa;Englund, Janet A.
通过比较6-11个月、12-17个月和18-23个月未接种疫苗的儿童对流感疫苗抗原的免疫应答，我们评估了年龄对三价灭活流感疫苗（TIV）免疫原性的影响。在6-23个月大的儿童中，对乙肝病毒的抗体反应似乎随着年龄的增长而增加。尽管有这样的发现。即使在评估的最年轻年龄组中，TIV也具有免疫原性，进一步确立了其作为保护幼儿免受流感侵害的工具的价值。在评估改进疫苗以增强幼年儿童的TIV免疫原性和有效性时，应考虑年龄的作用。(C) 2010 Elsevier Ltd.版权所有。
We assessed the effect of age on immunogenicity to trivalent inactivated influenza vaccine (TIV) by comparing the immune responses to influenza vaccine antigens among three age cohorts of vaccine-naive children aged 6-11 months, 12-17 months, and 18-23 months. In children 6-23 months of age, antibody responses to TIV appear to increase with increasing age. Despite this finding. TIV was immunogenic even in the youngest age group evaluated, further establishing its value as a tool to protect young children from influenza. The role of age should be considered when assessing improved vaccines to enhance TIV immunogenicity and effectiveness in younger children. (C) 2010 Elsevier Ltd. All rights reserved.