Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: is a profibrotic agent
Schistosome infection of transgenic mice defines distinct and contrasting pathogenic roles for IL-4 and IL-13: is a profibrotic agent
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DOI：
10.4049/jimmunol.164.5.2585
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发表时间：
2000-03-01
影响因子：
4.4
通讯作者：
McKenzie, ANJ
中科院分区：
文献类型：
--
作者：
Fallon, PG;Richardson, EJ;McKenzie, ANJ
实验性曼氏血吸虫感染小鼠导致动态的2型细胞因子介导的病理过程。我们使用IL-4缺陷、IL-13缺陷和IL-4/13缺陷的小鼠来剖析这些细胞因子在曼氏血吸虫感染后免疫应答和病理发展中的作用。我们证明，虽然这两种细胞因子是必要的，以发展一个强大的Th 2细胞驱动的，嗜酸性粒细胞丰富的肉芽肿反应，他们也执行不同的功能，确定新的网站进行治疗干预。IL-13缺陷型小鼠在感染后的存活率显著提高，这与肝纤维化减少相关。相比之下，增加的死亡率在IL-4缺陷和IL-4/13缺陷小鼠中是明显的，并且这与肝细胞损伤和肠道病理学相关。因此，我们证明在动态2型细胞因子疾病过程中，IL-13对感染后的存活是有害的，而IL-4是有益的。
Experimental Schistosoma mansoni infections of mice lead to a dynamic type 2 cytokine-mediated pathological process, We have used IL-4-deficient, IL-13-deficient, and IL-4/13-deficient mice to dissect the role of these cytokines in the development of immune response and pathology following S, mansoni infection. We demonstrate that while both of these cytokines are necessary to develop a robust Th2 cell-driven, eosinophil-rich granuloma response, they also perform disparate functions that identify novel sites for therapeutic intervention. IL-13-deficient mice demonstrated significantly enhanced survival following infection, which correlated with reduced hepatic fibrosis. In contrast, increased mortality was manifest in IL-4-deficient and IL-4/13-deficient mice, and this correlated with hepatocyte damage and intestinal pathology, Therefore, we demonstrate that during a dynamic type 2 cytokine disease process IL-13 is detrimental to survival following infection, whereas IL-4 is beneficial.