Distant influences of amygdala lesion on visual cortical activation during emotional face processing
Distant influences of amygdala lesion on visual cortical activation during emotional face processing
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DOI：
10.1038/nn1341
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发表时间：
2004-11-01
影响因子：
25
通讯作者：
Dolan, RJ
中科院分区：
文献类型：
--
作者：
Vuilleumier, P;Richardson, MP;Dolan, RJ
情感视觉刺激会引起视觉皮层的增强反应。为了测试这是否反映了杏仁核对感觉处理的调节影响，我们在患有内侧颞叶硬化的人类患者中使用了事件相关的功能磁共振成像（fMRI）。 26 名杏仁核、海马体或两者都有病变的患者，加上 13 名匹配的健康对照者，在显示器上看到与任务相关或与任务无关的位置的恐惧或中性面孔的图片。当面部处于与任务相关的位置时，所有受试者都表现出梭状皮层激活增加。当健康人和海马体受损的人看到可怕的面孔时，梭状皮层和枕叶皮层的激活都会增加，但杏仁核受损的人的情况却并非如此，尽管视觉区域的结构完好无损。杏仁核损伤与梭状皮层情绪激活水平之间的参数关系也证明了杏仁核的远程影响。我们的数据表明，结合功能磁共振成像和病变方法可以帮助揭示遥远但相互联系的大脑区域之间功能调节影响的来源。
Emotional visual stimuli evoke enhanced responses in the visual cortex. To test whether this reflects modulatory influences from the amygdala on sensory processing, we used event-related functional magnetic resonance imaging (fMRI) in human patients with medial temporal lobe sclerosis. Twenty-six patients with lesions in the amygdala, the hippocampus or both, plus 13 matched healthy controls, were shown pictures of fearful or neutral faces in task-relevant or task-irrelevant positions on the display. All subjects showed increased fusiform cortex activation when the faces were in task-relevant positions. Both healthy individuals and those with hippocampal damage showed increased activation in the fusiform and occipital cortex when they were shown fearful faces, but this was not the case for individuals with damage to the amygdala, even though visual areas were structurally intact. The distant influence of the amygdala was also evidenced by the parametric relationship between amygdala damage and the level of emotional activation in the fusiform cortex. Our data show that combining the fMRI and lesion approaches can help reveal the source of functional modulatory influences between distant but interconnected brain regions.