Which motor disorder in Parkinson's disease indicates the true motor function of the basal ganglia?
Which motor disorder in Parkinson's disease indicates the true motor function of the basal ganglia?
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帕金森病中的哪种运动障碍表明基底神经节的真正运动功能？
DOI：
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
C. Marsden
中科院分区：
文献类型：
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作者：
C. Marsden
帕金森病在其早期阶段被认为是人类基底神经节功能障碍的最佳可用模型。帕金森氏病的阴性运动症状被认为是大脑该区域正常功能的最大线索。特别注意运动障碍。这些包括延迟启动和缓慢执行简单的快速运动，由于异常规范的初始激动剂活性。这可能会损害预测性运动动作，但这在帕金森病中被证明是保留的。更复杂的运动障碍，如重复性，并发性和顺序性运动动作，也是帕金森病的异常。这些不同的缺陷进行了讨论，在涉及电机方案的选择和排序，以形成一个电机计划，并启动和执行该电机计划的电机策略。现有证据表明，帕金森病患者无法自动执行学习的运动计划。
Parkinson's disease in its earlier stages is argued to be the best available model for human basal ganglia dysfunction. The negative motor symptoms of Parkinson's disease are considered to give the greatest clue to normal function of this region of the brain. Particular attention is given to disorders of movement. These include delayed initiation and slowed execution of simple fast movements, due to abnormal specification of initial agonist activity. This might compromise predictive motor action, but this is shown to be preserved in Parkinson's disease. Disorders of more complex movements, such as repetitive, concurrent and sequential motor actions, are also abnormal in Parkinson's disease. These various defects are discussed in terms of a motor strategy involving the selection and sequencing of motor programmes to form a motor plan, and the initiation and execution of that motor plan. On the evidence available, it is suggested that patients with Parkinson's disease are unable to automatically execute learnt motor plans.