The Comparative Tumorigenic Effects of Fission Neutrons and Cobalt-60 γ Rays in the B6CF1 Mouse
The Comparative Tumorigenic Effects of Fission Neutrons and Cobalt-60 γ Rays in the B6CF1 Mouse
复制标题
裂变中子和钴 60 γ 射线对 B6CF1 小鼠致瘤作用的比较
DOI：
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发表时间：
1992
期刊：
影响因子：
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通讯作者：
B. Carnes
中科院分区：
文献类型：
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作者：
D. Grahn;L. Lombard;B. Carnes
1971年至1986年期间，两性B6CF1 (C57BL/6 x BALB/c)小鼠在110+/-7天龄时接受单次、每周24次或每周60次剂量的裂变中子或60Co伽马射线。一小群雄性也暴露在伽马射线下，每天 22 小时，每周 5 天，持续 23 或 59 周，即每周 24 和 60 次系列的经过时间。对所有小鼠的自然寿命进行跟踪。可获得 32,000 只动物的大体病理学报告，以及约 19,000 只动物的组织病理学记录。大约 85% 的人死于一种或多种肿瘤性疾病。死亡时观察到的主要肿瘤是淋巴网状肿瘤（45-60%）、血管肿瘤（20%）或肺部肿瘤（35-50%）。 4% 到 10% 的人死于纤维肉瘤、肝细胞肿瘤、卵巢肿瘤以及哈氏、肾上腺和垂体肿瘤。将剂量反应方程（线性和线性二次）拟合到八个不同个体或肿瘤组的死亡和发生数据。通过控制截距对方程进行约束，并分别针对两种性别、两种辐射质量以及从第一次暴露起 600-799 天和 800-999 天的两个间隔的所有暴露模式进行拟合。 RBE 值源自剂量反应曲线的线性系数之比。 RBE 值随着剂量的延长而增加，这主要是由于延长伽马射线照射的有效性降低所致；然而，约 28% 的增加可归因于剂量延长引起的中子诱发损伤的增加。上皮组织来源的肿瘤的 RBE 值最高，结缔组织来源的肿瘤的 RBE 值最低。显着值的范围从大约 2 到超过 50。非肿瘤性疾病约占所有死亡的 5%，其中 10% 属于不明原因。这两个类别都没有对辐射质量或暴露模式的差异做出反应。
In the period from 1971 to 1986, both sexes of the B6CF1 (C57BL/6 x BALB/c) mouse were exposed at 110 +/- 7 days of age to single, 24 once-weekly or 60 once-weekly doses of fission neutrons or 60Co gamma rays. A small group of males was also exposed to gamma rays for 22 h/day, 5 days/week, for either 23 or 59 weeks, the elapsed times for the 24 and 60 once-weekly series. All mice were followed for their natural lifetimes. A gross pathology report is available on 32,000 animals, and a histopathology record is available on about 19,000. About 85% died with or from one or more neoplastic diseases. The principal tumors observed at death were of lymphoreticular (45-60%), vascular (20%), or pulmonary (35-50%) origin. From 4 to 10% died with fibrosarcomas, hepatocellular tumors, ovarian tumors, and tumors of the Harderian, adrenal, and pituitary glands. Dose-response equations (linear and linear-quadratic) were fitted to the data for deaths from and occurrences of eight different individual or groups of tumors. Equations were constrained through the control intercepts and fitted separately for the two sexes, the two radiation qualities, and all exposure patterns for the two intervals of 600-799 days and 800-999 days from first exposure. RBE values were derived from the ratios of linear coefficients of dose-response curves. RBE values increased as dose was protracted, largely due to the reduced effectiveness of protracted gamma irradiation; however, about 28% of the increase can be attributed to the increase in neutron-induced injury caused by dose protraction. Highest RBE values were seen for tumors of epithelial tissue origin and the lowest for tumors of connective tissue origin. The range for significant values was from about 2 to over 50. Nonneoplastic diseases accounted for about 5% of all deaths, and 10% were classified as from unknown causes. Neither category responded to differences in radiation quality or exposure patterns.