Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury
Synapse formation of the cortico-spinal axons is enhanced by RGMa inhibition after spinal cord injury
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DOI：
10.1016/j.brainres.2007.10.038
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发表时间：
2007-12-19
期刊：
影响因子：
2.9
通讯作者：
Yamashita, Toshihide
中科院分区：
文献类型：
--
作者：
Kyoto, Akihiro;Hata, Katsuhiko;Yamashita, Toshihide
几种蛋白质已被鉴定为成年脊椎动物中枢神经系统损伤后轴突再生的抑制剂。排斥性导向分子（RGMa）被认为是有效的髓鞘衍生的神经突生长抑制剂。在大鼠中，RGMa抑制增强了受损轴突的生长并促进了脊髓损伤（SCI）后的功能恢复。在这里，我们证明了RGMa抑制诱导脊髓损伤后备用轴突投射的突触重排。鞘内施用RGMa的功能阻断抗体增强了具有胸脊髓半切的大鼠的颈部区域中皮质脊髓束的解剖突触形成。这些发现表明，抑制突触重排以及轴突生长抑制在成年脊髓可能有助于脊髓损伤后的功能恢复的限制。(c)2007 Elsevier B，V.保留所有权利。
Several proteins have been identified as inhibitors of axonal regeneration following injury of the adult vertebrate central nervous system. The repulsive guidance molecule (RGMa) is considered a potent myelin-derived neurite outgrowth inhibitor. in rats, RGMa inhibition enhances the growth of injured axons and promotes functional recovery after spinal cord injury (SCI). Here, we demonstrate that RGMa inhibition induces synaptic rearrangements of spared axonal projections after SCI. Intrathecal administration of a function-blocking antibody to RGMa enhances anatomical synapse formation of the corticospinal tract in the cervical region of rats with thoracic spinal cord hemisection. These findings suggest that the suppression of synaptic rearrangements as well as axon growth inhibition in the adult spinal cord may contribute to the limitation of functional recovery after SCI. (c) 2007 Elsevier B,V. All rights reserved.