Reverberation of recent visual experience in spontaneous cortical waves.
Reverberation of recent visual experience in spontaneous cortical waves.
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DOI:
10.1016/j.neuron.2008.08.026
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发表时间:
2008-10-23
期刊:
影响因子:
16.2
通讯作者:
Dan, Yang
中科院分区:
文献类型:
--
作者:
Han, Feng;Caporale, Natalia;Dan, Yang
Spontaneous waves of activity propagating across large cortical areas may play important roles in sensory processing and circuit refinement. However, whether these waves are in turn shaped by sensory experience remains unclear. Here we report that visually evoked cortical activity reverberates in subsequent spontaneous waves. Voltage-sensitive dye imaging in rat visual cortex showed that following repetitive presentation of a given visual stimulus, spatiotemporal activity patterns resembling the evoked response appear more frequently in the spontaneous waves. This effect is specific to the response pattern evoked by the repeated stimulus, and it persists for several minutes without further visual stimulation. Such wave-mediated reverberation could contribute to short-term memory and help to consolidate the transient effects of recent sensory experience into long-lasting cortical modifications.
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