Working Memory Abilities Among Children Treated for Medulloblastoma: Parent Report and Child Performance
Working Memory Abilities Among Children Treated for Medulloblastoma: Parent Report and Child Performance
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DOI：
10.1093/jpepsy/jsu009
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发表时间：
2014-06-01
影响因子：
3.6
通讯作者：
Gajjar, Amar
中科院分区：
文献类型：
--
作者：
Knight, Sarah J.;Conklin, Heather M.;Gajjar, Amar
目的采用基于父母和成绩的测量方法，研究髓母细胞瘤患儿术后5年工作记忆的发展轨迹。方法对167例髓母细胞瘤患者进行回顾性分析。连续5年在预定的时间点进行WM评估。结果有一个微妙的，统计学上显着增加父母对WM的关注，再加上一个统计学上显着下降的年龄标准化分数的性能为基础的措施。然而，整个组的平均分数在父母和性能为基础的措施仍然在年龄预期的范围。后颅窝综合征一直与较差的WM相关。年龄较小的治疗和较高的治疗强度与更大的负面变化WM性能只。结论根据父母的报告和表现，大多数接受髓母细胞瘤治疗的儿童在年龄适当的范围内显示WM。然而，随着时间的推移和确定的亚组风险增加的微妙的负面变化突出了对该人群进行持续监测的必要性。
Objective We investigated the 5-year postsurgical developmental trajectory of working memory (WM) in children with medulloblastoma using parent and performance-based measures. Method This study included 167 patients treated for medulloblastoma. Serial assessments of WM occurred at predetermined time points for 5 years. Results There was a subtle, statistically significant increase in parental concern about WM, coupled with a statistically significant decrease in age-standardized scores on performance-based measures. However, whole-group mean scores on both parent and performance-based measures remained in the age-expected range. Posterior fossa syndrome was consistently associated with poorer WM. Younger age at treatment and higher treatment intensity were associated with greater negative change in WM performance only. Conclusions Most children treated for medulloblastoma display WM within the age-appropriate range according to parent report and performance. However, the subtle negative changes over time and identified subgroups at increased risk highlight the need for ongoing monitoring of this population.