Effect of lipid characteristics on the structure of transmembrane proteins
Effect of lipid characteristics on the structure of transmembrane proteins
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DOI：
10.1016/s0006-3495(98)74059-7
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发表时间：
1998-09-01
影响因子：
3.4
通讯作者：
Safran, SA
中科院分区：
文献类型：
--
作者：
Dan, N;Safran, SA
已知包埋蛋白的活性随脂质特性而变化。事实上，已经表明，除非某些非双层形成脂质（即，非零自发曲率）存在。在本文中，我们表明，膜施加跨膜蛋白的线张力。在1-100 kT/蛋白质的数量级上的线张力随脂质性质和蛋白质构型而变化。因此，由不同脂质组成的膜有利于不同的蛋白质构象。模型预测与Keller等人（Biophys. J.1993，65：23-27）关于丙甲霉素通道的传导性。
The activity of embedded proteins is known to vary with lipid characteristics. Indeed, it has been shown that some cell-membrane proteins cannot function unless certain non-bilayer-forming lipids (i.e., nonzero spontaneous curvature) are present. In this paper we show that membranes exert a line tension on transmembrane proteins. The line tension, on the order of 1-100 kT/protein, varies with the lipid properties and the protein configuration. Thus, membranes composed of different lipids favor different protein conformations. Model predictions are in excellent agreement with the data of Keller et al, (Biophys. J. 1993, 65:23-27) regarding the conductance of alamethicin channels.