Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.
Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins.
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DOI：
10.1016/j.biocel.2016.02.005
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发表时间：
2016-04
期刊：
影响因子：
--
通讯作者：
Wei W
中科院分区：
文献类型：
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作者：
Zheng N;Wang Z;Wei W
F-box蛋白是E3泛素连接酶复合物SKP1-cullin 1-F-box蛋白（SCF）类型的亚基，已被证实在调控各种细胞过程中发挥关键作用，如细胞周期、细胞增殖、细胞凋亡、迁移、侵袭和转移。最近，大量证据表明，F-box蛋白通过调控细胞周期蛋白的泛素化和随后的降解，在肿瘤发生过程中起着至关重要的作用，而这一过程的失调会导致异常的细胞周期进程，最终导致肿瘤发生。因此，在这篇综述中，我们描述了F-box蛋白在及时调节细胞周期中的关键作用。此外，我们通过生物化学研究、工程小鼠模型和病理基因改变，讨论了F-box蛋白如何通过靶向细胞周期相关蛋白参与肿瘤发生。我们的结论是，F-box蛋白的抑制剂可能有希望的治疗潜力，部分通过控制异常细胞周期进展的癌症治疗。
F-box proteins, subunits of SKP1-cullin 1-F-box protein (SCF) type of E3 ubiquitin ligase complexes, have been validated to play a crucial role in governing various cellular processes such as cell cycle, cell proliferation, apoptosis, migration, invasion and metastasis. Recently, a wealth of evidence has emerged that F-box proteins is critically involved in tumorigenesis in part through governing the ubiquitination and subsequent degradation of cell cycle proteins, and dysregulation of this process leads to aberrant cell cycle progression and ultimately, tumorigenesis. Therefore, in this review, we describe the critical role of F-box proteins in the timely regulation of cell cycle. Moreover, we discuss how F-box proteins involve in tumorigenesis via targeting cell cycle-related proteins using biochemistry studies, engineered mouse models, and pathological gene alternations. We conclude that inhibitors of F-box proteins could have promising therapeutic potentials in part through controlling of aberrant cell cycle progression for cancer therapies.