PANoptosis: A New Insight Into Oral Infectious Diseases.
PANoptosis: A New Insight Into Oral Infectious Diseases.
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DOI：
10.3389/fimmu.2021.789610
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发表时间：
2021
影响因子：
7.3
通讯作者：
Zhao W
中科院分区：
文献类型：
--
作者：
Jiang W;Deng Z;Dai X;Zhao W
口腔微生物组是人体中最复杂和最密集的微生物生态系统之一，包括细菌、古细菌、真菌、原生动物和病毒。口腔微生物菌群的失调是导致口腔感染性疾病的起始因素。感染是一个复杂的生物学过程，涉及病原体和宿主之间的相互作用，这通常导致程序性细胞死亡的激活。研究表明，多种口腔感染性疾病均涉及细胞凋亡、细胞凋亡和细胞坏死。对细胞死亡途径之间的串扰的进一步理解已经导致焦亡、凋亡和坏死性凋亡被整合为单个术语：PAN凋亡。全脑下垂是免疫反应的多方面因素，与感染性疾病、自身免疫和癌症具有重要的病理生理学相关性。因此，它在检测和消除细胞内病原体的先天免疫细胞中起着重要作用。除了流感病毒感染和耶尔森氏菌感染的巨噬细胞的经典模型之外，其他研究已经将PAN凋亡的范围扩大到包括其他微生物，以及在巨噬细胞以外的细胞类型中的潜在作用。本文就口腔病原菌引起的炎症和组织破坏的病理生理机制进行综述。我们提出了一个概述不同的病原体，可能会导致激活的PAN细胞，沿着的功能后果的PAN细胞在口腔感染性疾病的背景下。为了促进我们对免疫学的理解，我们还探索了微生物在宿主细胞内进行免疫逃避和复制的策略。对宿主和病原体之间通过PANoptosis的相互作用的更好理解将指导针对口腔感染性疾病的治疗策略的发展。
The oral microbiome, one of the most complex and intensive microbial ecosystems in the human body, comprises bacteria, archaea, fungi, protozoa, and viruses. Dysbiosis of the oral microbiome is the initiating factor that leads to oral infectious diseases. Infection is a sophisticated biological process involving interplay between the pathogen and the host, which often leads to activation of programmed cell death. Studies suggest that pyroptosis, apoptosis, and necroptosis are involved in multiple oral infectious diseases. Further understanding of crosstalk between cell death pathways has led to pyroptosis, apoptosis, and necroptosis being integrated into a single term: PANoptosis. PANoptosis is a multifaceted agent of the immune response that has important pathophysiological relevance to infectious diseases, autoimmunity, and cancer. As such, it plays an important role in innate immune cells that detect and eliminate intracellular pathogens. In addition to the classical model of influenza virus-infected and Yersinia-infected macrophages, other studies have expanded the scope of PANoptosis to include other microorganisms, as well as potential roles in cell types other than macrophages. In this review, we will summarize the pathophysiological mechanisms underlying inflammation and tissue destruction caused by oral pathogens. We present an overview of different pathogens that may induce activation of PANoptosis, along with the functional consequences of PANoptosis in the context of oral infectious diseases. To advance our understanding of immunology, we also explore the strategies used by microbes that enable immune evasion and replication within host cells. Improved understanding of the interplay between the host and pathogen through PANoptosis will direct development of therapeutic strategies that target oral infectious diseases.
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