Prognostic factors of clinically stage I and II oral tongue carcinoma - A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features
Prognostic factors of clinically stage I and II oral tongue carcinoma - A comparative study of stage, thickness, shape, growth pattern, invasive front malignancy grading, Martinez-Gimeno score, and pathologic features
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DOI：
10.1002/hed.10094
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发表时间：
2002-06-01
影响因子：
2.9
通讯作者：
Wei, WI
中科院分区：
文献类型：
--
作者：
Yuen, APW;Lam, KY;Wei, WI
目的.本研究旨在评估不同的预后模型，包括阶段，肿瘤厚度，形状，肿瘤浸润前沿的恶性程度，Martinez-Gimeno评分和病理特征在预测早期T1和T2口腔舌鳞状细胞癌的亚临床淋巴结转移，局部复发和生存。本研究结果将对病人的管理有重要的指导意义。对72例临床T1、T2期舌癌舌切除标本行3 mm厚连续切片，观察其病理学特征。比较不同模型对亚临床淋巴结转移、局部复发和生存的预测价值。在所有评估的肿瘤参数和预测模型中，肿瘤厚度是唯一对亚临床淋巴结转移、局部复发和生存具有显著预测价值的重要因素。采用3-mm和9-mm分割，肿瘤厚度≤ 3-mm的亚临床淋巴结转移率为8%，局部复发率为0%，5年无瘤生存率为100%;肿瘤厚度> 3 - 9 mm的亚临床淋巴结转移率为44%，局部复发率为7%，5年无瘤生存率为76%;大于9 mm的肿瘤有53%的亚临床淋巴结转移，24%的局部复发，66%的5年无瘤生存率。早期舌癌的治疗应考虑肿瘤厚度。(C)2002 Wiley Periodicals，Inc.
Purpose. This study aims at evaluation of the different prognostic models, including stage, tumor thickness, shape, malignancy grading of tumor invasive front, Martinez-Gimeno score, and pathologic features in the prediction of subclinical nodal metastasis, local recurrence, and survival of early T1 and T2 oral tongue squamous cell carcinoma. The results will have important implication for the management of patients.Patients and Methods. Seventy-two clinically T1 and T2 glossectomy specimens of oral tongue carcinoma were serially sectioned in 3-mm thickness for the evaluation of various pathologic features. The prognostic value in the prediction of subclinical nodal metastasis, local recurrence, and survival of different models were compared.Results. Among all the tumor parameters and predictive models being evaluated, tumor thickness was the only significant factor that had significant predictive value for subclinical nodal metastasis, local recurrence, and survival. With the use of 3-mm and 9-mm division, tumor of up to 3-mm thickness has 8% subclinical nodal metastasis, 0% local recurrence, and 100% 5-year actuarial disease-free survival; tumor thickness of more than 3 mm and up to 9 mm had 44% subclinical nodal metastasis, 7% local recurrence, and 76% 5-year actuarial disease-free survival; tumor of more than 9 mm had 53% subclinical nodal metastasis, 24% local recurrence, and 66% 5-year actuarial disease-free survival.Conclusions. Tumor thickness should be considered in the management planning of patients with early oral tongue carcinoma. (C) 2002 Wiley Periodicals, Inc.