A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later
A simple sleep EEG marker in childhood predicts brain myelin 3.5 years later
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DOI：
10.1016/j.neuroimage.2019.05.072
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发表时间：
2019-10-01
期刊：
影响因子：
5.7
通讯作者：
Kurth, Salome
中科院分区：
文献类型：
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作者：
LeBourgeois, Monique K.;Dean, Douglas C.;Kurth, Salome
流行病学研究表明，儿童睡眠不足会对认知和情绪产生负面影响;然而，这些观察结果的生理基础仍然没有得到充分研究。我们检验了儿童期深睡眠慢波活动的地形分布预测3.5年后大脑白色物质微结构（髓鞘）的假设。健康儿童在基线（n = 13;年龄2.4-8.0岁）和随访（n = 14;年龄5.5-12.2岁）时接受睡眠高密度EEG。在随访时，还对髓磷脂（髓磷脂水组分）和皮质形态进行了定量。我们的调查揭示了三个主要发现。(1)基线时的额叶/枕叶（F/O）比值强烈预测随访时的全脑髓鞘。(2)在随访时，F/O比仅与脑髓磷脂存在极轻微（负）相关。(3)皮质形态与F/O比无关，无论是在基线还是在随访时。我们的研究结果支持这一假设，即在儿童发育过程中，睡眠中的脑电图标记物纵向预测脑髓鞘含量。数据扩展了以前的研究结果报告之间的联系脑电图标记的睡眠需要和皮质形态，通过支持睡眠是一个必要的组成部分，大脑的基本过程，特别是髓鞘，成熟的假设。根据睡眠有助于神经发育过程的总体理论，慢性睡眠不足是否会对发育敏感期的白色髓磷脂微结构生长产生负面影响仍有待研究。
Epidemiological research reveals that insufficient sleep in children has negative cognitive and emotional consequences; however, the physiological underpinnings of these observations remain understudied. We tested the hypothesis that the topographical distribution of deep sleep slow wave activity during the childhood predicts brain white matter microstructure (myelin) 3.5 y later. Healthy children underwent sleep high-density EEG at baseline (n = 13; ages 2.4-8.0 y) and follow-up (n = 14; ages 5.5-12.2 y). At follow-up, myelin (myelin water fraction) and cortical morphology were also quantified. Our investigation revealed 3 main findings. (1) The Frontal/Occipital (F/O)-ratio at baseline strongly predicted whole brain myelin at follow-up. (2) At follow-up, the F/O-ratio was only minimally (negatively) linked to brain myelin. (3) Cortical morphology was not related to the F/O-ratio, neither at baseline nor at follow-up. Our results support the hypothesis that during child development EEG markers during sleep longitudinally predict brain myelin content. Data extend previous findings reporting a link between EEG markers of sleep need and cortical morphology, by supporting the hypothesis that sleep is a necessary component to underlying processes of brain, and specifically myelin, maturation. In line with the overarching theory that sleep contributes to neurodevelopmental processes, it remains to be investigated whether chronic sleep loss negatively affects white matter myelin microstructure growth during sensitive periods of development.