S-100 ANTIGEN IN CEREBROSPINAL-FLUID AS A POSSIBLE INDEX OF CELL INJURY IN THE NERVOUS-SYSTEM
S-100 ANTIGEN IN CEREBROSPINAL-FLUID AS A POSSIBLE INDEX OF CELL INJURY IN THE NERVOUS-SYSTEM
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DOI：
10.1016/0022-510x(80)90133-1
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发表时间：
1980-01-01
影响因子：
4.4
通讯作者：
RIGON, G
中科院分区：
文献类型：
--
作者：
MICHETTI, F;MASSARO, A;RIGON, G
在患有精神障碍或各种神经系统疾病的[人]受试者的CSF中，使用单特异性抗S-100抗血清，通过微量补体结合试验检测神经系统特异性S-100抗原的存在。在大多数神经系统疾病患者的CSF中可检测到该抗原，其特征在于神经实质中的明显病变，而在活动期可能没有广泛神经病变的受试者的CSF中通常不存在该抗原。CSF中S-100的存在可能是神经实质活动性细胞损伤的一个指标。
The presence of the nervous system-specific S-100 antigen was tested by microcomplement fixation assay with a monospecific anti-S-100 antiserum in CSF of [human] subjects suffering from psychiatric disorders or various neurological diseases. The antigen was detectable in the CSF of most of the patients with neurological diseases characterized by an appreciable lesion in the nervous parenchyma, whereas it was generally absent from CSF of subjects presumably free from an extensive neurological lesion in the active phase. It is possible that the presence of S-100 in CSF might be an index of active cell injury in the nervous parenchyma.