TAT conjugated, FITC doped silica nanoparticles for bioimaging applications

TAT conjugated, FITC doped silica nanoparticles for bioimaging applications
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DOI:
10.1039/b411916a
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发表时间:
2004-01-01
影响因子:
4.9
通讯作者:
Mericle, RA
Mericle, RA
中科院分区:
化学2区
文献类型:
--
作者:
Santra, S;Yang, H;Mericle, RA

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报道了70 nm大小的单分散TAT(一种细胞穿透肽,CPP)缀合的、FITC(异硫氰酸荧光素)掺杂的二氧化硅纳米颗粒(TAT-FSNPs)的油包水(w/o)微乳液合成;使用TAT-FSNPs成功地标记了人肺腺癌(A549)细胞(体外)和大鼠脑组织(体内)。
Water-in-oil (w/o) microemulsion synthesis of 70 nm size monodisperse TAT ( a cell penetrating peptide, CPP) conjugated, FITC ( fluorescein isothiocyanate) doped silica nanoparticles (TAT-FSNPs) is reported; human lung adenocarcinoma (A549) cells ( in vitro) and rat brain tissue ( in vivo) were successfully labeled using TAT-FSNPs.