GSTM1 Copy Number and Kidney Disease in People With HIV.
GSTM1 Copy Number and Kidney Disease in People With HIV.
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DOI：
10.1016/j.ekir.2022.05.003
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发表时间：
2022-08
影响因子：
6
通讯作者：
Winkler, Cheryl A.
中科院分区：
文献类型：
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作者：
Hung, Rachel K. Y.;Rosenberg, Kerry-Lee;David, Victor;Binns-Roemer, Elizabeth;Booth, John W.;Hilton, Rachel;Fox, Julie;Burns, Fiona;Ustianowski, Andrew;Cosgrove, Catherine;Hamzah, Lisa;Burns, James E.;Clarke, Amanda;Chadwick, David;Price, David A.;Kegg, Stephen;Campbell, Lucy;Bramham, Kate;Sabin, Caroline A.;Post, Frank A.;Winkler, Cheryl A.
氧化应激与慢性肾脏病（CKD）的发病机制和进展有关。活性氧簇产生增加和抗氧化防御能力降低之间的不平衡会导致下游细胞信号传导中断，随后导致肾细胞凋亡和衰老、纤维化和血管损伤。1因此，提高减轻氧化应激能力的遗传变异可能对CKD的发展具有保护作用。谷胱甘肽-S-转移酶在促氧化剂物质与谷胱甘肽的结合中发挥作用，以促进活性氧物质的消除。GSTM 1是编码一种这样的同工酶的基因。该基因拷贝数经历了基因缺失和扩增，因此染色体没有拷贝，1个拷贝，或者在罕见情况下，2个拷贝的基因。酶活性需要两个拷贝的活性等位基因（单倍不足）;那些无效等位基因的纯合子，GSTM 1（0），完全缺乏酶的生产。具有非活性GSTM 1基因型（GSTM 1 0/0或1/0）的个体已被发现处于常见恶性肿瘤、动脉粥样硬化、冠心病和CKD进展的较高风险中。S1，S2本研究旨在调查GSTM 1基因型和流行的CKD之间的关系和GSTM 1和APOL 1携带者状态之间的相互作用，在英国的一个队列的黑人艾滋病毒感染者。第五、六条
Oxidative stress has been implicated in the pathogenesis and progression of chronic kidney disease (CKD). An imbalance between increased production of reactive oxygen species and reduced antioxidant defenses results in disruption to downstream cellular signaling and subsequent renal cell apoptosis and senescence, fibrosis, and vascular injury. 1 Genetic variants that improve the capacity to mitigate oxidative stress may therefore be protective against the development of CKD.The glutathione-S-transferases play a role in the conjugation of prooxidant species with glutathione to facilitate the elimination of reactive oxygen species. GSTM1 is the gene encoding one such isoenzyme. This gene copy number has undergone gene deletion and expansion so chromosomes have no copies, 1 copy or, in rare cases, 2 copies of the gene. Two copies of the active allele are required for enzymatic activity (haploinsufficiency); those homozygous for the null allele, GSTM1 (0), completely lack enzyme production. Individuals with the inactive GSTM1 genotypes (GSTM1 0/0 or 1/0) have been found to be at higher risk of common malignancies, atherosclerosis, coronary heart disease, and CKD progression. S1, S2 This study sought to investigate the relationship between GSTM1 genotype and prevalent CKD and the interaction between GSTM1 and APOL1 carrier status, 2, 3, 4 in a cohort of Black people with HIV in the United Kingdom. 5, 6
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影响因子：
6
作者：
Masimango MI;Jadoul M;Binns-Roemer EA;David VA;Sumaili EK;Winkler CA;Limou S
通讯作者：
Limou S
影响因子：
13.6
作者：
Tin, Adrienne;Scharpf, Robert;Grams, Morgan E.
通讯作者：
Grams, Morgan E.
影响因子：
3.7
作者：
Zhang, Yanfei;Zafar, Waleed;Lee, Ming Ta Michael
通讯作者：
Lee, Ming Ta Michael
影响因子：
15.1
作者：
Hung RKY;Santana-Suarez B;Binns-Roemer E;Campbell L;Bramham K;Hamzah L;Fox J;Burns JE;Clarke A;Vincent R;Jones R;Price DA;Onyango D;Harber M;Hilton R;Booth JW;Sabin CA;Winkler CA;Post FA;GEN-AFRICA study group
通讯作者：
GEN-AFRICA study group
GSTM1调节尿毒症环境中内皮粘附分子的表达。
影响因子：
--
作者：
Jerotic D;Suvakov S;Matic M;Alqudah A;Grieve DJ;Pljesa-Ercegovac M;Savic-Radojevic A;Damjanovic T;Dimkovic N;McClements L;Simic T
通讯作者：
Simic T