Clinical features and management of Meniere's disease patients with drop attacks
Clinical features and management of Meniere's disease patients with drop attacks
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梅尼埃病跌倒发作患者的临床特征及治疗
DOI：
10.1007/s00405-018-5260-5
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发表时间：
2019-03-01
影响因子：
2.6
通讯作者：
Dai, Chunfu
中科院分区：
文献类型：
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作者：
Wu, Qianru;Li, Xuanyi;Dai, Chunfu
目的本研究的目的是调查梅尼埃病（MD）伴或不伴跌倒发作（DAs）患者临床特征的变化，包括病史、听力功能、前庭功能和内淋巴积水（EH）程度，并探讨鼓室内庆大霉素（ITG）治疗缓解DAs的效果。方法总共177例单侧明确的DAs患者。 MD 患者入组，包括 16 名有 DA 的患者和 161 名无 DA 的患者。分析听力测试、前庭诱发肌源电位（VEMP）和磁共振成像（MRI）的结果。 13例DA患者接受单次ITG治疗并随访。结果DA组MD病程明显长于对照组(p=0.007)。与没有 DA 的 MD 患者相比，具有 DA 的 MD 患者听力损失明显更大，EH 更差 (p
PurposeThe aims of the present study are to investigate the variations in clinical features, including medical history, hearing function, vestibular function, and degree of endolymphatic hydrops (EH), in Meniere's disease (MD) patients with and without drop attacks (DAs), and to examine the efficacy of intratympanic gentamicin (ITG) treatment in alleviating DAs.MethodsIn total, 177 unilateral definite MD patients, including 16 patients with DAs and 161 patients without DAs, were enrolled. The results of hearing test, vestibular-evoked myogenic potentials (VEMPs), and magnetic resonance imaging (MRI) were analyzed. Thirteen patients with DAs received a single ITG treatment and were followed up.ResultsThe disease course of MD in the DA group was significantly longer than that in the control group (p=0.007). MD patients with DAs had significantly greater hearing loss and worse EH than MD patients without DAs (p