Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
Effects of long-term antioxidant supplementation and association of serum antioxidant concentrations with risk of metabolic syndrome in adults
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DOI：
10.3945/ajcn.2009.27635
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发表时间：
2009-08-01
影响因子：
7.1
通讯作者：
Ahluwalia, Namanjeet
中科院分区：
文献类型：
--
作者：
Czernichow, Sebastien;Vergnaud, Anne-Claire;Ahluwalia, Namanjeet
背景资料：有限的观察证据表明代谢综合征（MetS）患者体内抗氧化剂浓度较低;很少有随机对照试验研究多种抗氧化剂对MetS风险的影响。目的：目的是研究补充抗氧化剂7.5年对代谢综合征发病率的影响，以及基线血清抗氧化剂浓度与代谢综合征的前瞻性风险之间的流行病学关联。MetS.设计：参与维生素和矿物质抗氧化剂补充（SUPplementation en Vitamines et Mineraux AntioXydants，SU.VI.MAX）一级预防试验的成年人（n = 5220）被随机分配接受含有营养剂量的抗氧化剂（维生素C和E、β-胡萝卜素、锌和硒）组合的补充剂或安慰剂。受试者在基线时无代谢综合征，并随访7.5年。结果：抗氧化剂补充7.5年不影响代谢综合征的风险。然而，基线血清抗氧化剂β-胡萝卜素和维生素C浓度与代谢综合征的风险呈负相关;最高与最低三分位数相比的校正比值比（和95%CI）分别为0.34（0.21，0.53;趋势P = 0.0002）和0.53（0.35，0.80;趋势P = 0.01）。基线血清锌浓度与发生代谢综合征的风险呈正相关;校正的比值比与最低三分位数相比，最高三分位数（和95% CI）为1.81（1.20，2.72;趋势P = 0.01）。实验发现，在一般良好的情况下，补充抗氧化剂没有任何有益的效果-营养不良人口的死亡率与最近关于抗氧化剂补充剂缺乏功效的报告一致。然而，观察到的MetS风险与基线血清抗氧化剂浓度之间的关系（这可能反映了与整体饮食模式的相关性）确实支持了当前食用富含抗氧化剂食物的建议。该试验在临床试验中注册。gov as NCT 00272428.美国临床营养杂志2009;90：329-35。
Background: Limited observational evidence suggests lower antioxidant concentrations in individuals with the metabolic syndrome (MetS); few randomized controlled trials have addressed the effect of multiple antioxidants on the risk of MetS.Objective: The objective was to examine the effect of antioxidant supplementation for 7.5 y on the incidence of MetS and the epidemiologic association between baseline serum antioxidant concentrations and the prospective risk of MetS.Design: Adults (n = 5220) participating in the SUpplementation en VItamines et Mineraux AntioXydants (SU.VI.MAX) primary prevention trial were randomly assigned to receive a supplement containing a combination of antioxidants (vitamins C and E, beta-carotene, zinc, and selenium) at nutritional doses or a placebo. Subjects were free of MetS at baseline and were followed for 7.5 y.Results: Antioxidant supplementation for 7.5 y did not affect the risk of MetS. Baseline serum antioxidant concentrations of beta-carotene and vitamin C, however, were negatively associated with the risk of MetS; the adjusted odds ratios (and 95% CIs) for the highest compared with the lowest tertile were 0.34 (0.21, 0.53; P for trend = 0.0002) and 0.53 (0.35, 0.80; P for trend = 0.01), respectively. Baseline serum zinc concentrations were positively associated with the risk of developing MetS; the adjusted odds ratio (and 95% CI) for the highest compared with the lowest tertile was 1.81 (1.20, 2.72; P for trend = 0.01).Conclusions: The experimental finding of no beneficial effects of antioxidant supplementation in a generally well-nourished population is consistent with recent reports of a lack of efficacy of antioxidant supplements. However, the relations observed between the risk of MetS and baseline serum antioxidant concentrations, which probably reflect associations with overall dietary patterns, do support the current recommendations to consume antioxidant-rich foods. This trial was registered at clinicaltrials. gov as NCT00272428. Am J Clin Nutr 2009;90:329-35.