Fabrication of patterned calcium cross-linked alginate hydrogel films and coatings through reductive cation exchange
Fabrication of patterned calcium cross-linked alginate hydrogel films and coatings through reductive cation exchange
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DOI：
10.1016/j.carbpol.2015.05.021
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发表时间：
2015-10-20
影响因子：
11.2
通讯作者：
Melman, Artem
中科院分区：
文献类型：
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作者：
Bruchet, Marion;Melman, Artem
海藻酸钙交联水凝胶广泛应用于靶向给药、组织工程、创伤治疗等生物医学领域。我们开发了一种在均相铁(III)交联的海藻酸水凝胶中利用还原阳离子交换制备与钙离子交联的均相海藻酸水凝胶的方法。用钙盐和抗坏血酸钠处理铁(III)交联的海藻酸水凝胶，可将铁(III)阳离子还原为铁(II)，并瞬间被钙离子取代，产生均一的离子交联水凝胶。或者，在氯化钙存在的情况下，可以使用牺牲性光还原剂通过光化学还原来执行阳离子交换。这种方法可以通过光化学构图铁(III)交联的海藻酸钙水凝胶，然后将铁离子光化学还原交换成钙来制备图案化的海藻酸钙水凝胶。(C)2015爱思唯尔有限公司。保留所有权利。
Calcium cross-linked alginate hydrogels are widely used in targeted drug delivery, tissue engineering, wound treatment, and other biomedical applications. We developed a method for preparing homogeneous alginate hydrogels cross-linked with Ca2+ cations using reductive cation exchange in homogeneous iron(III) cross-linked alginate hydrogels. Treatment of iron(III) cross-linked alginate hydrogels with calcium salts and sodium ascorbate results in reduction of iron(III) cations to iron(II) that are instantaneously replaced with Ca2+ cations, producing homogeneous ionically cross-linking hydrogels. Alternatively, the cation exchange can be performed by photochemical reduction in the presence of calcium chloride using a sacrificial photoreductant. This approach allows fabrication of patterned calcium alginate hydrogels through photochemical patterning of iron(III) cross-linked alginate hydrogel followed by the photochemical reductive exchange of iron cations to calcium. (C) 2015 Elsevier Ltd. All rights reserved.