Immune responses to final exams in healthy and asthmatic adolescents.
Immune responses to final exams in healthy and asthmatic adolescents.
复制标题
健康和哮喘青少年对期末考试的免疫反应。
DOI：
10.1097/00006199-199701000-00003
复制
发表时间：
1997
期刊：
影响因子：
2.5
通讯作者：
Ershler,WB
中科院分区：
文献类型：
--
作者：
Kang,DH;Coe,CL;McCarthy,DO;Ershler,WB
针对健康和哮喘青少年的疾病症状报告，研究了他们对学业压力源的免疫反应。87名高中生完成了为期两周的健康日记，并在学期中、期末考试和考试后提供了三份血样。在考试周期间，所有学生都表现出了与基线相比的显著免疫变化：自然杀伤细胞活性显著降低，而淋巴细胞增殖和中性粒细胞超氧化物释放显著增加。在考试后期间，这些免疫变化趋于接近基线，但增强的中性粒细胞反应性继续上升。总体而言，哮喘受试者和对照组的免疫学反应相似。适当的医疗管理可能是造成这种相似性的原因。然而，考试后恢复模式和应激源后炎症细胞功能持续激活的细微组间差异可能值得进一步研究。
Immune responses to an academic stressor were examined in healthy and asthmatic adolescents with regard to their illness symptom reports. Eighty-seven high school students completed a health diary for 2 weeks and provided three blood samples during midsemester, final-exam, and postexam periods. During exam week, all students showed significant immunological alterations from baseline: Natural killer cell activity was significantly lower, whereas lymphocyte proliferation and neutrophil superoxide release were significantly higher. These immune changes tended to return toward baseline during the postexam period, but the enhanced neutrophil reactivity continued to rise. Overall, immunological responses were similar between asthmatic subjects and controls. Appropriate medical management may have accounted for this similarity. However, subtle group differences in the postexam recovery pattern and a continuous activation of inflammatory cell function following a stressor may warrant further investigation.