Immunosuppression of mice injected with heterologous anti-immunoglobulin heavy chain antisera.
Immunosuppression of mice injected with heterologous anti-immunoglobulin heavy chain antisera.
复制标题
注射异源抗免疫球蛋白重链抗血清的小鼠的免疫抑制。
DOI：
10.1084/jem.135.6.1316
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发表时间：
1972-06-01
期刊：
影响因子：
--
通讯作者：
Jutila JW
中科院分区：
文献类型：
--
作者：
Manning DD;Jutila JW
新生小鼠注射兔抗血清已被证明完全丧失对绵羊红细胞的直接和间接斑块形成反应，以及血清IgM的丧失和所有其他血清免疫球蛋白的严重抑制。类似的抗γ - 1 -γ - 2或抗γ - 1抗体的注射影响间接反应的丧失，但诱导血清Ig水平的相对较小的改变。延迟抗微球治疗的开始，直到年轻的成年导致对斑块形成反应和血清Ig水平的影响有所减弱，但会触发高水平的异常含微球蛋白的释放。对无胸腺基因小鼠的抗抑制表明，至少部分抑制的靶细胞来自骨髓。讨论了体液抗体产生细胞系成熟的工作假设，因为它与这些数据有关。
Neonatal injection of mice with rabbit anti-µ antiserum has been shown to produce complete loss of direct and indirect plaque-forming responses to sheep erythrocytes as well as loss of serum IgM and severe depressions of all other serum immunoglobulins. Similar injection of anti-γ1γ2 or anti-γ1 antibodies effects a loss of the indirect response but induces relatively minor alterations in serum Ig levels. Delaying initiation of anti-µ treatment until young adulthood results in a somewhat diminished effect on plaque-forming responses and serum Ig levels but triggers the release of high serum levels of an aberrant µ-bearing protein. Anti-µ suppression of genetically thymusless mice indicates that at least part of the target cells for suppression are bone marrow derived. A working hypothesis for the maturation of humoral antibody-producing cell lines as it relates to these data is discussed.