Toward the elucidation of biomolecular damage in liquid water near tracks caused by ion beams
Toward the elucidation of biomolecular damage in liquid water near tracks caused by ion beams
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阐明离子束在轨道附近液态水中造成的生物分子损伤
DOI：
10.11470/jsaprev.220413
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Takeshi Kai
中科院分区：
文献类型：
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作者：
Hidetsugu Tsuchida;Takuya Majima;Takeshi Kai
1.背景使用质子或碳离子束的带电粒子放射疗法，其涉及癌组织中的高剂量浓度，在许多国家如欧洲、美国和亚洲，正在被用于涉及辐射的癌症治疗[1]。也有研究阐明了原子水平上辐射的生物效应[2，3]。已经提出了DNA损伤的新机制，例如由低于DNA组成分子的电离阈值的低能电子引起的DNA双链断裂，以及与原子间库仑衰变相关的分子损伤[4，5]。活细胞由约70%的水分子和生物分子（蛋白质、脂质、碳水化合物和核酸）组成，因此在考虑辐射对活生物体的影响时，了解液态水的影响非常重要。众所周知，水是参与辐射对生物体的直接和间接影响的二次电子和自由基的来源。最近的研究表明，水环境可以抑制对生物分子的损害[6]。这被称为保护效应，其中通过将施加在生物分子上的辐射能量分配到分子周围的水分子来抑制对生物分子的损伤。近年来，已经有研究更详细地调查液态水对生物分子辐射损伤的影响[7-10]。在我们的实验室中，我们正在对加速器和液体的离子束之间的相互作用进行基础研究，以便从物理和化学角度更好地理解布拉格峰区域发生的生物分子损伤的基本过程[11-14]。这个过程在粒子束癌症治疗中很重要。本文介绍了将液体物质引入真空和在真空中用离子束照射液体的方法的研究和发展。解释了MeV能量离子对液态水中生物分子的损伤机理。
1. BackgroundCharged particle radiotherapy using proton or carbon ion beams, which involves high dose concentration in cancer tissue, is being performed for cancer treatment involving radiation in many countries such as Europe, the United States, and Asia [1]. There has also been research to elucidate the biological effects of radiation at the atomic level [2, 3]. New mechanisms of DNA damage have been proposed, such as DNA double-strand breaks caused by low-energy electrons below the ionization threshold of the constituent molecules of DNA, and molecular damage associated with interatomic Coulombic decay [4, 5]. Living cells are composed of about 70% water molecules and biomolecules (proteins, lipids, carbohydrates, and nucleic acids), so it is important to know the effects of liquid water when considering the effects of radiation on living organisms. It is well known that water is a source of secondary electrons and radicals involved in the direct and indirect effects of radiation on living organisms. Recent research has shown that the water environment can suppress damage to biomolecules [6]. This is called a protective effect, where the damage to biomolecules is suppressed by distributing the energy of radiation that is exerted on biomolecules to water molecules surrounding the molecules. In recent years, there has been research to investigate in more detail the effects of liquid water on radiation damage to biomolecules [7–10]. In our laboratory, we are conducting fundamental research on the interaction between ion beams from accelerators and liquids to better understand the elementary process of biomolecular damage that occurs in the Bragg peak region from both physics and chemistry perspectives [11–14]. This process is important in particle beam cancer therapy. This paper describes the research and development of methods for introducing a liquid substance into a vacuum and irradiating an ion beam to a liquid in a vacuum. We explain the damage mechanism of biomolecules in liquid water by MeV energy ions.