Bov-B-mobilized SINEs in vertebrate genomes
Bov-B-mobilized SINEs in vertebrate genomes
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DOI：
10.1016/j.gene.2007.09.021
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发表时间：
2008-01-15
期刊：
影响因子：
3.5
通讯作者：
Kramerov, Dmitri A.
中科院分区：
文献类型：
--
作者：
Gogolevsky, Konstantin P.;Vassetzky, Nikita S.;Kramerov, Dmitri A.
在啮齿目（Rodentia）的角足鼠（Pedetes capensis）基因组中发现了两个新的短逆转录酶家族（西内斯）。其中，Ped-1起源于5S rRNA，而另一个，Ped-2，起源于tRNA衍生的SINE ID。与目前大多数活跃的哺乳动物西内斯动员L1长反转录转座子（LINE），Ped-1和Ped-2动员Bov-B，广泛分布的RTE分支的LINE家族。这些西内斯的3'部分来源于Bov-B的5'和3'区域中的两个序列。LINE衍生部分的这种二分结构已在迄今已知的所有Bov-B动员的西内斯（AfroSINE、Bov-tA、Mar-1和Ped-1/2）中揭示，这将它们与仅具有3'LINE衍生部分的其它西内斯区分开。结构分析和Bov-B UNE和伙伴西内斯的分布支持Bov-B的水平转移，而西内斯独立出现在该LINE的谱系中。(c)2007 Elsevier B. V.保留所有权利。
Two new short retroposon families (SINEs) have been found in the genome of springhare Pedetes capensis (Rodentia). One of them, Ped-1 originated from 5S rRNA, while the other one, Ped-2, originated from tRNA-derived SINE ID. In contrast to most currently active mammalian SINEs mobilized by L1 long retrotransposon (LINE), Ped-1 and Ped-2 are mobilized by Bov-B, a LINE family of the widely distributed RTE clade. The 3' part of these SINEs originates from two sequences in the 5' and 3' regions of Bov-B. Such bipartite structure of the LINE-derived part has been revealed in all Bov-B-mobilized SINEs known to date (AfroSINE, Bov-tA, Mar-1 and Ped-1/2), which distinguishes them from other SINEs with only a 3' LINE-derived part. Structural analysis and the distribution of Bov-B UNEs and partner SINEs supports the horizontal transfer of Bov-B, while the SINEs emerged independently in lineages with this LINE. (c) 2007 Elsevier B.V. All rights reserved.