A comparison of patellofemoral cartilage morphology and deformation in anterior cruciate ligament deficient versus uninjured knees
A comparison of patellofemoral cartilage morphology and deformation in anterior cruciate ligament deficient versus uninjured knees
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DOI：
10.1016/j.jbiomech.2017.11.019
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发表时间：
2018-01-23
影响因子：
2.4
通讯作者：
DeFrate, Louis E.
中科院分区：
文献类型：
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作者：
Owusu-Akyaw, Kwadwo A.;Heckelman, Lauren N.;DeFrate, Louis E.
与一般人群相比，前十字韧带 (ACL) 缺陷患者的髌股关节 (PFJ) 骨关节炎 (OA) 发病率更高。尽管损伤后骨关节炎的原因是多因素的，但关节生物力学的改变可能使患者容易发生软骨退变。本研究旨在比较单侧 ACL 断裂受试者中 ACL 缺陷膝关节和完整膝关节的体内 PFJ 形态和力学。八名男性受试者接受了双膝基线 MRI 扫描。然后，他们进行了 60 次单腿跳跃，随后进行了运动后 MRI 扫描。对对侧膝盖重复此过程。将 MR 图像转换为软骨和骨骼的三维表面模型，以评估运动后的软骨厚度分布和应变。运动前，完好膝盖的髌骨软骨比 ACL 缺陷的膝盖明显厚 1.8%。作为对运动的反应，我们观察到 ACL 缺陷和完整膝盖的平均髌骨软骨应变分别为 5.4 +/- 1.1% 和 2.5 +/- 1.4%。重要的是，ACL 缺陷膝盖的髌骨软骨应变程度明显高于完整膝盖。然而，虽然滑车软骨的平均应变为 2.4 +/- 1.6%，但 ACL 缺陷和未受伤的膝盖之间的滑车软骨应变没有差异。总之，我们发现与未受伤的对侧膝盖相比，ACL 缺陷与髌骨软骨厚度减少和运动引起的髌骨软骨应变增加有关。 (C) 2017 Elsevier Ltd. 保留所有权利。
Anterior cruciate ligament (ACL) deficient patients have an increased rate of patellofemoral joint (PFJ) osteoarthritis (OA) as compared to the general population. Although the cause of post-injury OA is multi-factorial, alterations in joint biomechanics may predispose patients to cartilage degeneration. This study aimed to compare in vivo PFJ morphology and mechanics between ACL deficient and intact knees in subjects with unilateral ACL ruptures. Eight male subjects underwent baseline MRI scans of both knees. They then, performed a series of 60 single-legged hops, followed by a post-exercise MRI scan. This process was repeated for the contralateral knee. The MR images were converted into three-dimensional surface models of cartilage and bone in order to assess cartilage thickness distributions and strain following exercise. Prior to exercise, patellar cartilage was significantly thicker in intact knees as compared to ACL deficient knees by 1.8%. In response to exercise, we observed average patellar cartilage strains of 5.4 +/- 1.1% and 2.5 +/- 1.4% in the ACL deficient and intact knees, respectively. Importantly, the magnitude of patellar cartilage strain in the ACL deficient knees was significantly higher than in the intact knees. However, while trochlear cartilage experienced a mean strain of 2.4 +/- 1.6%, there was no difference in trochlear cartilage strain between the ACL deficient and uninjured knees. In summary, we found that ACL deficiency was associated with decreased patellar cartilage thickness and increased exercise-induced patellar cartilage strain when compared to the uninjured contralateral knees. (C) 2017 Elsevier Ltd. All rights reserved.