INHIBITORS OF GASTRIC LESIONS IN RAT
INHIBITORS OF GASTRIC LESIONS IN RAT
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DOI：
10.1111/j.2042-7158.1978.tb13214.x
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发表时间：
1978-01-01
影响因子：
3.3
通讯作者：
WEST, GB
中科院分区：
文献类型：
--
作者：
HAYDEN, LJ;THOMAS, G;WEST, GB
甲硫米特和美替拉明对大鼠应激性胃损伤的产生有抑制作用。吲哚美辛治疗引起的病变被美托咪胺抑制，但不被甲硫米特抑制。在幽门结扎的大鼠中，阿司匹林治疗诱导的那些不受任何抗组胺药物的影响。口服谷氨酰胺抑制所有3个系统的病变产生，而阿司匹林口服显着增强it.Sodium水杨酸抑制吲哚美辛诱导的病变和幽门结扎大鼠阿司匹林产生的。水杨酸铜抑制应激诱导的病变，并像阿司匹林铜，它显着降低阿司匹林产生的病变程度。应激诱导的损伤产生提供了用于测试抗溃疡药物的合适的动物模型，因为与大多数人类胃溃疡一样，应激诱导的损伤产生被受体抑制剂如甲硫米特抑制。
The production by stress of gastric lesions in rats was inhibited by metiamide and by mepyramine. Lesions induced by indomethacin treatment were inhibited by mepyramine but not by metiamide. Those induced by aspirin treatment in pylorus-ligated rats were not affected by either antihistamine drug. Oral glutamine inhibited lesion production in all 3 systems whereas aspirin orally markedly potentiated it. Sodium salicylate inhibited both indomethacin-induced lesions and those produced by aspirin in pylorus-ligated rats. Copper salicylate inhibited stress-induced lesions and like copper aspirinate, it markedly reduced the extent of lesions produced by aspirin. Stress-induced lesion production offers a suitable animal model for testing anti-ulcer drugs since, like most human gastric ulcers, it is inhibited by receptor inhibitors like metiamide.