Genetic component of sensorimotor capacity in rats.
Genetic component of sensorimotor capacity in rats.
复制标题
大鼠感觉运动能力的遗传成分。
DOI：
10.1152/physiolgenomics.00137.2002
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
Britton,StevenL
中科院分区：
文献类型：
--
作者：
Koch,LaurenGerard;Britton,StevenL
Creation of generalized genetic models for low and high sensorimotor capacity would be important tools for resolution of this complex trait. As proof-of-principle we estimated phenotypic variation and narrow-sense heritability (h2) of sensorimotor capacity in 19 families of genetically heterogeneous N:NIH rats and in 11 strains of inbred rats. Sensorimotor capacity was defined as the time a rat remained on an accelerating rotorod. N:NIH rats recorded variation in rotorod scores that ranged from 3- to 7-fold. The value of h2, estimated from offspring-parent regression across one generation, was 0.68 for females and 0.74 for males in N:NIH rats. In inbred rats, h2was estimated by partitioning phenotypic variation into additive genetic and environmental components and averaged 0.39 in females and 0.48 in males. These results demonstrate a heritable component to sensorimotor capacity sufficient for success in developing contrasting genetic models by divergent artificial selection in rats.
