Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone.
Alteration in osmolarity of inhaled aerosols cause bronchoconstriction and cough, but absence of a permeant anion causes cough alone.
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发表时间：
1984-02
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通讯作者：
W. Eschenbacher;H. Boushey;D. Sheppard
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作者：
W. Eschenbacher;H. Boushey;D. Sheppard
为了确定咳嗽和支气管收缩是否是由吸入气雾剂的渗透压或离子浓度的改变引起的，并确定气雾剂中的特定离子是否重要，我们让9名轻度哮喘受试者吸入各种溶液，同时记录咳嗽并测量特定气道阻力。为了分别评价改变渗透压和离子浓度的影响，我们给予低渗蒸馏水（0 mosm）、等渗氯化钠（308 mosm）、等渗葡萄糖水溶液（308 mosm）、高渗氯化钠（1，232 mosm）以及葡萄糖水溶液和氯化钠（1，232 mosm）的气雾剂。为了评估无支气管收缩的咳嗽，我们让受试者在吸入相同的气雾剂之前吸入异丙肾上腺素。为了确定特定离子的缺乏是否在引起咳嗽或支气管收缩中起重要作用，我们让受试者吸入溴化钠、葡萄糖酸钠和赖氨酸盐酸盐的等渗溶液。我们发现，在轻度哮喘受试者中，吸入气雾剂的渗透压浓度偏离等渗透压浓度是支气管收缩的刺激因素。在等渗透压浓度下缺乏离子不会刺激支气管收缩，但缺乏渗透性阴离子会刺激咳嗽。因此，我们发现咳嗽和支气管收缩对吸入气溶胶的反应可以分开。
To determine whether cough and bronchoconstriction result from alterations in the osmolarity or alterations in the ion concentration of inhaled aerosols and to determine if the specific ions in the aerosol are important, we had 9 subjects with mild asthma inhale various solutions while we recorded cough and measured specific airway resistance. To evaluate the effects of altering osmolarity and ion concentration separately, we administered aerosols of hypo-osmolar distilled water (0 mosm), iso-osmolar sodium chloride (308 mosm), iso-osmolar dextrose in water (308 mosm), hyperosmolar sodium chloride (1,232 mosm), and a hyperosmolar solution of dextrose and sodium chloride (1,232 mosm). To evaluate cough without bronchoconstriction, we had the subjects inhale metaproterenol before inhaling the same aerosols. To determine whether the absence of a specific ion was important in causing cough or bronchoconstriction, we had the subjects inhale iso-osmolar solutions of sodium bromide, sodium gluconate, and lysine monohydrochloride. We found that alteration in osmolarity away from iso-osmolarity of inhaled aerosols is a stimulus for bronchoconstriction in subjects with mild asthma. Absence of ions in the presence of iso-osmolarity is not a stimulus for bronchoconstriction, but the absence of a permeant anion is a stimulus for cough. Thus, we found that the responses of cough and bronchoconstriction to inhaled aerosols can be separated.