Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
Advances in the use of synthetic combinatorial chemistry: Mixture-based libraries
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DOI：
10.1038/nm0103-118
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发表时间：
2003-01-01
期刊：
影响因子：
82.9
通讯作者：
Houghten, Richard A.
中科院分区：
文献类型：
--
作者：
Pinilla, Clemencia;Appel, Jon R.;Houghten, Richard A.
导致组合化学爆炸性增长的概念和技术方法始于大约20年前。在过去的十年中，组合化学随着新的化学、技术的改进而不断发展，最重要的是，它在鉴定研究和药物发现计划的活性化合物方面的效用得到了明确的证明。本文介绍了概念和实践的突破，已成为关键的合成组合方法的发展，包括最新的发展和应用的混合为基础的组合库。
The conceptual and technical approaches that led to the explosive growth of combinatorial chemistry began approximately 20 years ago. In the past decade, combinatorial chemistry has continued to expand with new chemistries, technological improvements and, most importantly, a clear demonstration of its utility in the identification of active compounds for research and drug-discovery programs. This article describes the conceptual and practical breakthroughs that have been critical for the development of synthetic combinatorial methods and includes the most recent developments and applications of mixture-based combinatorial libraries.