Thyroid-Stimulating Hormone (TSH) Binding to Extrathyroidal Human Tissues: TSH and Thyroid- Stimulating Immunoglobulin Effects on Adenosine 3′,5′- Monophosphate in Testicular and Adrenal Tissues*
Thyroid-Stimulating Hormone (TSH) Binding to Extrathyroidal Human Tissues: TSH and Thyroid- Stimulating Immunoglobulin Effects on Adenosine 3′,5′- Monophosphate in Testicular and Adrenal Tissues*
复制标题
促甲状腺激素 (TSH) 与甲状腺外人体组织的结合：TSH 和促甲状腺免疫球蛋白对睾丸和肾上腺组织中 3′,5′- 单磷酸腺苷的影响*
DOI：
--
复制
发表时间：
1979
期刊：
影响因子：
--
通讯作者：
R. Volpe
中科院分区：
文献类型：
--
作者：
K. Trokoudes;A. Sugenoya;E. Hazani;V. Row;R. Volpe
摘要 [125I]牛 TSH 与人甲状腺、睾丸、脂肪、肾上腺、肝脏、肾脏、胰腺和肺细胞膜的结合已被研究。发现前四种组织具有相当高的亲和力常数值；其余组织缺乏高亲和力位点。除脂肪组织外，前四种组织的高亲和力位点的能力相似。 100–20,000 μIU/ml 的牛 TSH 浓度刺激人冷冻保存睾丸切片中 cAMP 的产生增加。格雷夫斯病血清中 40% 的促甲状腺免疫球蛋白 (TSI) 样本也增加了人类睾丸 cAMP 的产生。此外，牛 TSH 导致整个脱壳大鼠睾丸中 cAMP 显着升高。 25% 的 TSI 测试样本也引发了这种反应。大鼠肾上腺的反应是 cAMP 产量增加至 1,000 μU/ml 牛 TSH 浓度。高亲和力牛TSH和TS的生理意义...
ABSTRACT Binding of [125I]bovine TSH to human thyroid, testicular, fat, adrenal, liver, kidney, pancreas, and lung cell membranes has been studied. The first four tissues were foundto have comparable high affinity constant values; the rest of the tissues lacked high affinity sites. With the exception of fat tissue, the capacities of the high affinity sites of the first four tissues were similar. Bovine TSH concentrations of 100–20,000 μIU/ml stimulatedincreased cAMP production in human cryopreserved testicular slices. Forty percent of the specimens of thyroid-stimulating immunoglobulin (TSI) from Graves' disease sera also increased human testicular cAMP production. In addition, bovine TSH caused a significant rise in cAMP in the whole decapsulated rat testis. Twenty-five percent of the TSI specimens tested also induced such responses. The rat adrenal gland responded with increased cAMP production to concentrations of 1,000 μU/ml bovine TSH. The physiological significance of high affinity bovine TSH and TS...