Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue
Systemic Staphylococcus aureus infection mediated by Candida albicans hyphal invasion of mucosal tissue
复制标题
DOI：
10.1099/mic.0.083485-0
复制
发表时间：
2015-01-01
期刊：
影响因子：
2.8
通讯作者：
Shirtliff', Mark E.
中科院分区：
文献类型：
--
作者：
Schlecht, Lisa Marie;Peters, Brian M.;Shirtliff', Mark E.
白色念珠菌和金黄色葡萄球菌通常在生物膜相关感染的情况下共同分离。C.白色念珠菌可通过从圆形酵母形态转变为侵入性菌丝形态而引起全身性疾病。或者，系统S.金黄色葡萄球菌感染是通过宿主上皮层的破裂而接种引起的，尽管许多患者没有记录的进入入口。我们描述了一种新的策略，S。金黄色葡萄球菌能够侵入宿主组织并通过粘附于白色念珠菌的侵入性菌丝成分而传播。体外和离体研究结果表明，葡萄球菌的念珠菌菌丝元素的特异性结合。梭白念珠菌细胞壁粘附素Als3p结合多种葡萄球菌粘附素。此外，C. albicans转运S.金黄色葡萄球菌进入组织并在口腔共定植模型中引起播散性感染。这些结果表明C.白色念珠菌可促进S.金黄色葡萄球菌穿过粘膜屏障，导致共定植患者的全身感染。
Candida albicans and Staphylococcus aureus are often co-isolated in cases of biofilm-associated infections. C. albicans can cause systemic disease through morphological switch from the rounded yeast to the invasive hyphal form. Alternatively, systemic S. aureus infections arise from seeding through breaks in host epithelial layers although many patients have no documented portal of entry. We describe a novel strategy by which S. aureus is able to invade host tissue and disseminate via adherence to the invasive hyphal elements of Candida albicans. In vitro and ex vivo findings demonstrate a specific binding of the staphylococci to the candida hyphal elements. The C. albicans cell wall adhesin Als3p binds to multiple staphylococcal adhesins. Furthermore, Als3p is required for C. albicans to transport S. aureus into the tissue and cause a disseminated infection in an oral co-colonization model. These findings suggest that C. albicans can facilitate the invasion of S. aureus across mucosal barriers, leading to systemic infection in co-colonized patients.