TRAUMATIC BRAIN INJURY PRODUCES IMPAIRMENTS IN LONG-TERM AND RECENT MEMORY
TRAUMATIC BRAIN INJURY PRODUCES IMPAIRMENTS IN LONG-TERM AND RECENT MEMORY
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DOI：
10.1016/0006-8993(93)91014-j
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发表时间：
1993-06-18
期刊：
影响因子：
2.9
通讯作者：
BECKER, DP
中科院分区：
文献类型：
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作者：
GORMAN, LK;SHOOK, BL;BECKER, DP
人类创伤性脑损伤（TBI）通常会产生神经抑制和较长时间的记忆损伤，临床定义为创伤后遗忘症。一个可靠地再现与TBI相关的生理变化的动物模型被用来评估脑损伤后的记忆缺陷。在脑外伤之前，大鼠被训练去执行四项任务中的一项，评估运动表现、长期或近期记忆。将大鼠随机分为三组（单纯麻醉组、假手术组和液体叩击组）。在用于制造脑外伤的液体冲击后，对大鼠进行了6次试验。第一次治疗发生在实验操作后1-2分钟。接下来的5次训练遵循实验操作前的训练计划。长期记忆的差异仅在第一次术后测试中出现。在所有6个测试过程中都发现了近期记忆表现的差异。记忆缺陷与运动缺陷明显分离。在人类头部损伤和实验性TBI损伤后观察到的类似记忆缺陷表明，液体冲击是一种有效的方法，可以研究脑损伤的潜在神经生物学机制和可能的临床干预措施。
Traumatic brain injury (TBI) in humans typically produces neurological suppression and a longer lasting impairment of memory clinically defined as post-traumatic amnesia. An animal model that reliably reproduces the physiological changes associated with TBI was used to assess the memory deficits following brain injury. Prior to TBI, rats were trained to perform one of four tasks that assessed either motor performance, long-term or recent memory. Rats were randomly assigned to one of three groups (anesthesia only, sham operation or fluid percussion). Following fluid percussion, used to produce TBI, rats were tested for 6 test sessions. The first session occurred 1-2 min after the experimental manipulation. The next 5 sessions followed the training schedule maintained prior to experimental manipulation. Differences in long-term memory occurred only in the first post-operative test session. Differences in recent memory performance were found across all 6 test sessions. The memory deficits were clearly dissociated from motor deficits. The similar memory deficits observed following human head injury and the experimentally produced TBI injury demonstrate that fluid percussion is a useful approach to examine underlying neurobiological mechanisms involved in head injury and possible clinical interventions.