Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment.
Recent Progress in Alzheimer's Disease Research, Part 3: Diagnosis and Treatment.
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DOI：
10.3233/jad-160907
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Albert MS
中科院分区：
文献类型：
--
作者：
Hane FT;Robinson M;Lee BY;Bai O;Leonenko Z;Albert MS
阿尔茨海默病（AD）研究领域在过去几十年中呈指数级增长，特别是自从从AD患者的脑的死后检查中分离和鉴定淀粉样蛋白-β以来。最近，《阿尔茨海默病杂志》（JAD）发表了约300篇研究报告，被认为是自2010年以来AD领域最有影响力的研究报告。JAD的读者被要求对这些最有影响力的报道进行投票。在这篇由3部分组成的综述中，我们回顾了300篇最有影响力的AD研究报告的结果，为JAD读者提供了一个随时可用的，但对当代研究状况的全面回顾。值得注意的是，这个多部分的审查确定了AD研究的“最热门”领域，为高级研究人员和新进入该领域的研究人员提供指导，了解AD研究中最紧迫的领域。本综述的第1部分涵盖了分子和宏观尺度上的发病机制。第2部分回顾遗传学和流行病学，第3部分包括诊断和治疗。这部分的审查，诊断和治疗，审查了最新的诊断标准，生物标志物，成像和治疗AD。
The field of Alzheimer’s disease (AD) research has grown exponentially over the past few decades, especially since the isolation and identification of amyloid-β from postmortem examination of the brains of AD patients. Recently, the Journal of Alzheimer’s Disease (JAD) put forth approximately 300 research reports which were deemed to be the most influential research reports in the field of AD since 2010. JAD readers were asked to vote on these most influential reports. In this 3-part review, we review the results of the 300 most influential AD research reports to provide JAD readers with a readily accessible, yet comprehensive review of the state of contemporary research. Notably, this multi-part review identifies the “hottest” fields of AD research providing guidance for both senior investigators as well as investigators new to the field on what is the most pressing fields within AD research. Part 1 of this review covers pathogenesis, both on a molecular and macro scale. Part 2 review genetics and epidemiology, and part 3 covers diagnosis and treatment. This part of the review, diagnosis and treatment, reviews the latest diagnostic criteria, biomarkers, imaging, and treatments in AD.