Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat
Requirement of Prefrontal and Midbrain Regions for Rapid Executive Control of Behavior in the Rat
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DOI：
10.1016/j.neuron.2015.05.042
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发表时间：
2015-06-17
期刊：
影响因子：
16.2
通讯作者：
Brody, Carlos D.
中科院分区：
文献类型：
--
作者：
Duan, Chunyu A.;Erlich, Jeffrey C.;Brody, Carlos D.
为了研究快速的感觉运动重映射，我们开发了一种方法来训练大鼠的行为，在这种行为中，受试者在每次试验中都被提示应用感觉运动关联来朝向视觉目标（“Pro”）或远离它，朝向它的反面（“Anti'"）。多重行为不对称表明，反行为是认知要求，而亲更容易学习和执行。这与灵长类动物文献中的一个重要假设一致，即Anti需要前额叶皮质（PFC），而Pro可能由中脑上级丘（SC）介导。大鼠内侧前额叶皮质的药理学失活支持了其在抗中的预期作用。值得注意的是，双边SC失活大大削弱抗，而留下的Pro基本上是完整的。此外，SC失活消除了从Anti切换到Pro任务的性能成本。我们的研究结果建立了一个啮齿动物模型的单次试验感觉运动重映射，并建议SC在认知要求反任务的关键作用。
To study rapid sensorimotor remapping, we developed a method to train rats in a behavior in which subjects are cued, on each trial, to apply a sensorimotor association to orient either toward a visual target ("Pro'') or away from it, toward its reverse ("Anti''). Multiple behavioral asymmetries suggested that Anti behavior is cognitively demanding while Pro is easier to learn and perform. This is consistent with a prominent hypothesis in the primate literature that Anti requires prefrontal cortex (PFC), whereas Pro could be mediated by midbrain superior colliculus (SC). Pharmacological inactivation of rat medial PFC supported its expected role in Anti. Remarkably, bilateral SC inactivation substantially impaired Anti while leaving Pro essentially intact. Moreover, SC inactivation eliminated the performance cost of switching from Anti to Pro tasks. Our results establish a rodent model of single-trial sensorimotor remapping and suggest a critical role for SC in the cognitively demanding Anti task.