The placental transfer of IgG subclasses in human pregnancy.
The placental transfer of IgG subclasses in human pregnancy.
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DOI：
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发表时间：
1980-08
影响因子：
4.6
通讯作者：
R. Pitcher-Wilmott;P. Hindocha;C. Wood
中科院分区：
文献类型：
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作者：
R. Pitcher-Wilmott;P. Hindocha;C. Wood
使用径向免疫扩散方法，对来自 28 至 42 周不同妊娠期的 34 对母体和胎儿血清中的总 IgG 浓度和 IgG 四个亚类的浓度进行了评估。结果发现：（1）所有 IgG 亚类均可自由穿过人胎盘；（2）胎儿 IgG 及其各亚类水平超过足月妊娠时的母体水平；（3）胎龄与 IgG 及其各亚类胎盘转移之间存在密切的线性关系。
Total IgG concentrations and the concentrations of the four subclasses of IgG were estimated in thirty-four pairs of maternal and foetal sera from pregnancies of various gestations ranging from 28 to 42 weeks using the method of radial immunodiffusion. It was found that: (1) all subclasses of IgG cross the human placenta freely, (2) foetal levels of IgG and each subclass of IgG exceed maternal levels in full-term pregnancies and (3) there was a close linear relationship between gestational age and the placental transfer of IgG and each of its subclasses.