Does genetic testing result in behavioral health change? Changes in smoking behavior following testing for alpha-1 antitrypsin deficiency
Does genetic testing result in behavioral health change? Changes in smoking behavior following testing for alpha-1 antitrypsin deficiency
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DOI：
10.1207/s15324796abm3301_3
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发表时间：
2007-01-01
影响因子：
3.8
通讯作者：
Gilbert, Gregory E.
中科院分区：
文献类型：
--
作者：
Carpenter, Matthew J.;Strange, Charlie;Gilbert, Gregory E.
背景随着健康风险的基因检测变得越来越可用，研究检测对可改变的健康行为的前瞻性影响变得非常重要目的：本研究探讨了α-1抗胰蛋白酶（AAT）缺乏症的基因检测的影响，这种情况通常会导致暴露于香烟烟雾的个体肺气肿。我们评估了AAT测试，在家里进行，并与最低限度的接触（阅读材料，包括戒烟建议），是否会导致戒烟尝试和禁欲。方法：在接受AAT基因型后3个月，对一项更大规模的基因检测研究中确定的吸烟者（N = 199）进行调查。主要终点是戒烟尝试的发生率。结果如下：AAT严重不足的吸烟者报告24小时戒烟尝试的可能性（59%）明显高于测试正常的吸烟者（26%）。运营商有34%的退出尝试率。严重AAT缺乏的吸烟者比携带者和正常人更有可能寻求治疗信息，使用药物戒烟，并报告他们的吸烟量减少。3个月的戒烟率没有组间差异。结论：了解严重的AAT缺乏症，而不是携带者身份，可能会激励吸烟者戒烟。AAT检测经验可能会对其他遗传疾病的结果产生影响，这些遗传疾病具有可改变的健康行为。
Background. As genetic testing for health risk becomes increasingly available, it becomes important to study the prospective impact of testing on modifiable health behavior Purpose: This study examines the impact of genetic testing for alpha-1 antitrypsin (AAT) deficiency, a condition that usually results in emphysema in individuals exposed to cigarette smoke. We evaluated whether AAT testing, performed in the home and with minimal contact (reading materials including advice on cessation), results in quit attempts and abstinence. Methods: Identified smokers (N = 199) from a larger study of genetic testing were surveyed 3 months following receipt of their AAT genotype. The primary endpoint was the incidence of quit attempts. Results: Smokers who tested severely AAT deficient were significantly more likely to report a 24-hr quit attempt (59%) than were those who tested normal (26%). Carriers had a 34% quit attempt rate. Severely AAT deficient smokers were more likely than both carriers and normals to seek information on treatment, use pharmacotherapy for smoking cessation, and report greater reductions in their smoking. There were no group differences in 3-month abstinence rates. Conclusions: Knowledge of severe AAT deficiency, but not carrier status, may motivate smokers toward cessation. The AAT testing experience may have consequences for outcomes of other genetic conditions with modifiable health behaviors.