Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: The big picture
Pathway analysis of gene lists associated with platinum-based chemotherapy resistance in ovarian cancer: The big picture
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DOI：
10.1016/j.ygyno.2010.01.010
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发表时间：
2010-05-01
影响因子：
4.7
通讯作者：
Berns, Els M. J. J.
中科院分区：
文献类型：
--
作者：
Helleman, Jozien;Smid, Marcel;Berns, Els M. J. J.
Objective.卵巢癌是西方世界妇科癌症死亡的主要原因（Parkin等人，2005年）。总体5年生存率仅为30%（Moss和Kaye，2002），这在很大程度上是由于基于铂的化疗耐药性。在这项研究中，我们对9个已发表的与卵巢癌铂类耐药相关的基因集进行了通路分析，其中包括我们的一项研究。通过这项探索性研究，我们的目的是确定与卵巢癌铂类化疗耐药机制相关的重叠途径。进行基因本体论（GO）分析和不相容性途径分析（IPA）以确定与所有Unigene标识符或不相容性知识库相比，在9项研究（457个基因）的组合基因列表中哪些功能过程被差异地表示。GO和IPA分析结果产生了23个基因网络，并显示13个GO过程（>= 2倍富集），71个典型途径（p
Objective. Ovarian cancer is the leading cause of death from gynecological cancers in the Western world (Parkin et al., 2005). The overall 5-year survival is only 30% (Moss and Kaye, 2002), which is for a significant part due to platinum-based chemotherapy resistance. In this study, we performed a pathway analysis on nine published gene sets associated with platinum resistance in ovarian cancer, including a study by us. With this exploratory study, we aim to identify overlapping pathways associated with platinum-based chemotherapy resistance mechanisms in ovarian cancer.Methods. Gene Ontology (GO) analysis and Ingenuity Pathway Analysis (IPA) were performed to determine which functional processes were differentially represented in the combined gene lists of nine studies (457 genes) compared to all Unigene identifiers or the Ingenuity knowledge base.Results. The GO and IPA analysis resulted in the generation of 23 gene networks, and showed that 13 GO processes (>= 2 times enriched), 71 canonical pathways (p