SUBPLATE NEURONS PIONEER THE 1ST AXON PATHWAY FROM THE CEREBRAL-CORTEX
SUBPLATE NEURONS PIONEER THE 1ST AXON PATHWAY FROM THE CEREBRAL-CORTEX
复制标题
DOI：
10.1126/science.2475909
复制
发表时间：
1989-09-01
期刊：
影响因子：
56.9
通讯作者：
SHATZ, CJ
中科院分区：
文献类型：
--
作者：
MCCONNELL, SK;GHOSH, A;SHATZ, CJ
在神经系统的发育过程中，生长中的轴突必须穿越相当长的距离才能找到它们的目标。在昆虫中，这个问题部分由先驱神经元解决，当距离最小时，它们会铺设第一条轴突路径。这里描述了在发育中的哺乳动物端脑中存在一种类似的神经元。这些是亚板细胞，是大脑皮层有丝分裂后的第一批神经元。来自基板神经元的轴突穿过内囊并在胎儿早期侵入丘脑，甚至在皮质层5和6的神经元（其将形成成人皮质下投射）产生之前。在出生后的生活中，成年模式的轴突投射牢固建立后，大多数subplate神经元消失。这些观察结果提出了一种可能性，即由亚板细胞形成的早期轴突支架可能被证明是建立永久性皮质下投射所必需的。
During the development of the nervous system, growing axons must traverse considerable distances to find their targets. In insects, this problem is solved in part by pioneer neurons, which lay down the first axonal pathways when distances are at a minimum. Here the existence of a similar kind of neuron in the developing mammalian telencephalon is described. These are the subplate cells, the first postmitotic neurons of the cerebral cortex. Axons from subplate neurons traverse the internal capsule and invade the thalamus early in fetal life, even before the neurons of cortical layers 5 and 6, which will form the adult subcortical projections, are generated. During postnatal life, after the adult pattern of axonal projections is firmly established, most subplate neurons disappear. These observations raise the possibility that the early axonal scaffold formed by subplate cells may prove essential for the establishment of permanent subcortical projections.