Fabrication of calcium phosphate fibres through electrospinning and sintering of hydroxyapatite nanoparticles
Fabrication of calcium phosphate fibres through electrospinning and sintering of hydroxyapatite nanoparticles
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DOI：
10.1016/j.matlet.2013.04.110
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发表时间：
2013-09
影响因子：
3
通讯作者：
P. Mouthuy;A. Crossley;H. Ye
中科院分区：
文献类型：
--
作者：
P. Mouthuy;A. Crossley;H. Ye
磷酸钙（CaP）材料如合成羟基磷灰石（HA，Ca 10（PO 4）6·（OH）2）和β-磷酸三钙（β-TCP，Ca 3（PO 4）2）因其在骨组织工程和药物递送应用中的潜力而众所周知。将这些材料加工成亚微纤维可能有助于改善其生物相容性。本文提出了一种通过静电纺丝路线制备CaP亚微米纤维的新方法。在烧结温度（1100°C）下对填充有羟基磷灰石纳米颗粒的电纺聚合物纤维进行热处理，以引起纳米颗粒的聚集并蒸发聚合物基质。通过电子显微镜拍摄的图像显示，经处理的样品保持其亚微纤维形态。此外，傅里叶变换红外光谱，X射线衍射和X射线光电子能谱分析证实，所得到的纤维是由羟基磷灰石和磷酸三钙。
Calcium phosphate (CaP) materials such as synthetic hydroxyapatite (HA, Ca10(PO4)6·(OH)2) and β-tricalcium phosphate (β-TCP, Ca3(PO4)2) are well-known for their potential in bone tissue engineering and drug delivery applications. Processing such materials into submicrofibres might contribute to improve their biocompatibility. This paper presents a new method for creating CaP submicrofibres through the electrospinning route. A thermal treatment at sintering temperature (1100°C) was applied to electrospun polymer fibres filled with hydroxyapatite nanoparticles to cause aggregation of the nanoparticles and vaporise the polymer matrix. The images taken by electron microscopy revealed that the treated samples maintained their submicrofibrous morphology. Moreover, Fourier transform infrared spectroscopy, X-ray diffraction and X-ray photoelectron spectroscopy analysis confirmed that the resulting fibres are made of hydroxypatite and tricalcium phosphates.