Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
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DOI：
10.1093/aje/kwh018
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发表时间：
2004-01-15
影响因子：
5
通讯作者：
Fratiglioni, L
中科院分区：
文献类型：
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作者：
Karp, A;Kåreholt, I;Fratiglioni, L
在这项研究中，作者评估了低教育水平与阿尔茨海默病（AD）和痴呆症风险增加之间的关联是否可以通过基于职业的社会经济地位（SES）来解释。对来自瑞典斯德哥尔摩Kungsholmen项目的931名年龄大于或等于75岁的非痴呆受试者进行了为期3年的随访。共检测到101例痴呆症事件，其中76例涉及AD。受教育程度较低的受试者发生AD的校正相对风险为3.4（95%置信区间：2.0，6.0），SES较低的受试者发生AD的校正相对风险为1.6（95%置信区间：1.0，2.5）。当教育和社会经济地位被引入到同一模型中时，只有教育与AD显著相关。低教育程度与低或高SES的组合与类似的AD风险增加相关，但受过良好教育的低SES受试者的风险并不高。20岁时的低社会经济地位，即使在40岁或60岁时社会经济地位很高，也与风险增加有关;然而，当教育进入模型时，这种增加消失了。总之，低教育程度和AD风险增加之间的关联并不受成人社会经济地位或社会经济流动性的影响。这表明早期生活因素可能是相关的。
In this study, the authors evaluated whether the association between low educational level and increased risk of Alzheimer's disease (AD) and dementia may be explained by occupation-based socioeconomic status (SES). A cohort of 931 nondemented subjects aged greater than or equal to75 years from the Kungsholmen Project, Stockholm, Sweden, was followed for 3 years between 1987 and 1993. A total of 101 incident cases of dementia, 76 involving AD, were detected. Less-educated subjects had an adjusted relative risk of developing AD of 3.4 (95% confidence interval: 2.0, 6.0), and subjects with lower SES had an adjusted relative risk of 1.6 (95% confidence interval: 1.0, 2.5). When both education and SES were introduced into the same model, only education remained significantly associated with AD. Combinations of low education with low or high SES were associated with similar increased risks of AD, but well-educated subjects with low SES were not at high risk. Low SES at 20 years of age, even when SES was high at age 40 or 60 years, was associated with increased risk; however, this increase disappeared when education was entered into the model. In conclusion, the association between low education and increased AD risk was not mediated by adult SES or socioeconomic mobility. This suggests that early life factors may be relevant.