Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh
Incomplete correlation of serum vibriocidal antibody titer with protection from Vibrio cholerae infection in urban Bangladesh
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DOI：
10.1086/421275
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发表时间：
2004-06-15
影响因子：
6.4
通讯作者：
Calderwood, SB
中科院分区：
文献类型：
--
作者：
Saha, D;LaRocque, RC;Calderwood, SB
血清杀灭弧菌抗体是唯一公认的预防霍乱的预测因子，但自O139霍乱弧菌出现以来，没有收集到血清流行病学数据。在霍乱流行环境中，我们评估了杀弧菌抗体效价和霍乱保护力之间的关系。尽管较高的基线杀灭弧菌滴度与对O1霍乱弧菌的保护相关，但在一些滴度非常高的接触者中仍会发生感染。未发现基线杀灭弧菌效价与预防O139霍乱弧菌感染之间的关联。我们的发现表明，杀弧菌抗体不能完全预测对霍乱弧菌感染的保护作用。
The serum vibriocidal antibody is the only recognized predictor of protection from cholera, but no seroepidemiological data have been gathered since the emergence of Vibrio cholerae O139. We assessed the association between the vibriocidal antibody titer and protection from cholera in an endemic setting. Although a higher baseline vibriocidal titer correlated with protection from V. cholerae O1, infection still developed in some contacts with very high titers. No association between baseline vibriocidal titer and protection from V. cholerae O139 infection was found. Our findings suggest that the vibriocidal antibody is an incomplete predictor of protection from V. cholerae infection.