miRNA Deregulation in Cancer Cells and the Tumor Microenvironment.
miRNA Deregulation in Cancer Cells and the Tumor Microenvironment.
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miRNA在癌细胞和肿瘤微环境中的管制。
DOI：
10.1158/2159-8290.cd-15-0893
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发表时间：
2016-03
期刊：
影响因子：
28.2
通讯作者：
Sood AK
中科院分区：
文献类型：
--
作者：
Rupaimoole R;Calin GA;Lopez-Berestein G;Sood AK
microRNA（miRNAs）是非编码RNA家族的重要组成部分。肿瘤微环境和癌细胞之间相互作用的潜在机制涉及高度动态的因素，如缺氧和细胞类型，如癌症相关的成纤维细胞和巨噬细胞。虽然已知癌细胞中的miRNA水平会发生改变，但最近的证据表明肿瘤微环境在调节miRNA生物发生、甲基化和转录变化中起着关键作用。在这里，我们讨论了肿瘤细胞，肿瘤微环境和miRNA失调之间复杂的促肿瘤共生作用。
MicroRNAs (miRNAs) are a key component of the noncoding RNA family. The underlying mechanisms involved in the interplay between the tumor microenvironment and cancer cells involve highly dynamic factors such as hypoxia and cell types such as cancer-associated fibroblasts and macrophages. Although miRNA levels are known to be altered in cancer cells, recent evidence suggests a critical role for the tumor microenvironment in regulating miRNA biogenesis, methylation, and transcriptional changes. Here, we discuss the complex pro-tumorigenic symbiotic role between tumor cells, the tumor microenvironment, and miRNA deregulation.