GLUTATHIONE S-TRANSFERASE IN FORMATION OF CYANIDE FROM ORGANIC THIOCYANATES AND AS AN ORGANIC NITRATE REDUCTASE
GLUTATHIONE S-TRANSFERASE IN FORMATION OF CYANIDE FROM ORGANIC THIOCYANATES AND AS AN ORGANIC NITRATE REDUCTASE
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DOI：
10.1016/0006-291x(75)90349-6
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发表时间：
1975-01-01
影响因子：
3.1
通讯作者：
JAKOBY, WB
中科院分区：
文献类型：
--
作者：
HABIG, WH;KEEN, JH;JAKOBY, WB
有证据表明，谷胱甘肽S-转移酶是一组在谷胱甘肽和大量具有亲电子碳原子的化合物形成硫醚过程中具有活性的酶，也可以催化有机硝酸酯（例如硝酸甘油）形成亚硝酸和氧化型谷胱甘肽。此外，有机硫氰酸盐被这些酶裂解形成氰化物和相应的谷胱甘肽的不对称二硫化物。
Evidence is presented that glutathione S-transferases, a group of enzymes active in the formation of thioethers from glutathione and a large number of compounds with an electrophilic carbon atom, can also catalyze the formation of nitrous acid and oxidized glutathione from organic nitrate esters such as nitroglycerin. In addition, organic thiocyanates are cleaved by these enzymes to form cyanide and the respective asymmetric disulfide of glutathione.