Oncocytic metaplasia occurring in melanoma
Oncocytic metaplasia occurring in melanoma
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DOI：
10.1016/s1085-5629(03)00091-9
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发表时间：
2004-03-01
影响因子：
--
通讯作者：
Somach, SC
中科院分区：
文献类型：
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作者：
Jih, DM;Morgan, MB;Somach, SC
背景：嗜酸性细胞增生是一种细胞特征，其特征是由于线粒体积聚而导致嗜酸性细胞浆呈细颗粒状。虽然这种组织学特征可以在正常组织中发现，但在病理学上也被视为一种退行性现象。我们最近回顾了一个没有临床意义的嗜瘤性黑素细胞痣的谱。我们现在描述了黑色素瘤的类似变化。方法：我们回顾性分析了12例具有明显颗粒状嗜酸性细胞质的黑色素瘤，并完成了超微结构研究。我们从患者的医生那里获得了患者的病史和临床随访信息。结果：所有病例均为原发性黑色素瘤，多数病变黑色素瘤细胞呈明显的嗜瘤性增生。原位黑色素瘤和浸润性黑色素瘤均可见瘤细胞增生，其brreslow厚度范围很广（0.45-5.05 mm）。它发生在有无溃疡、消退、血管侵犯和肿瘤浸润淋巴细胞的情况下。超微结构研究显示黑色素细胞有大量扭曲的线粒体。结论：黑色素瘤能够以多种组织学形式出现，包括癌细胞改变。虽然我们的观察是初步的，但这种病理好奇心可能代表了一种退行性现象，对预后的重要性很小。(C) 2004爱思唯尔公司版权所有。
Background: Oncocytosis is a cellular feature characterized by the presence of a finely granular eosinophilic cytoplasm due to the accumulation of mitochondria. While this histologic trait can be found in normal tissues, it is also seen pathologically as a degenerative phenomenon. We recently reviewed a spectrum of oncocytic melanocytic nevi that did not have clinical significance. We now describe similar changes in melanoma. Methods: We retrospectively reviewed 12 melanomas noted to have prominent granular eosinophilic cytoplasm and completed ultrastructural studies. We obtained patient histories and clinical follow-up information from the patients' physicians. Results: All cases were primary melanomas and showed prominent oncocytosis in the majority of the lesional melanoma cells. Oncocytosis was observed in both melanoma in situ and invasive melanoma with a wide range of Breslow thicknesses (range, 0.45-5.05 mm). It occurred in the presence and absence of ulceration, regression, vascular invasion, and brisk tumor infiltrating lymphocytes. Ultrastructural studies revealed melanocytes with numerous distorted mitochondria. Conclusion: Melanoma is capable of presenting in a variety of histologic guises, including oncocytic change. While our observations are preliminary, this pathologic curiosity likely represents a degenerative phenomenon of little prognostic importance. (C) 2004 Elsevier Inc. All rights reserved.