Artificial myocardium with an artificial baroreflex system using nano technology.
Artificial myocardium with an artificial baroreflex system using nano technology.
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采用纳米技术的人工压力反射系统的人工心肌。
DOI：
10.1016/j.biopha.2003.08.016
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发表时间：
2003
期刊：
影响因子：
--
通讯作者：
S. Nitta
中科院分区：
文献类型：
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作者：
T. Yambe;Y. Shiraishi;M. Yoshizawa;A. Tanaka;K. Abe;F. Sato;H. Matsuki;M. Esashi;Y. Haga;S. Maruyama;T. Takagi;Yun Luo;E. Okamoto;Yutaka Kubo;M. Osaka;S. Nanka;Y. Saijo;Yoshiaki Mibiki;Tasuku Yamaguchi;M. Shibata;S. Nitta
对于充血性心力衰竭患者，哪里应该给予帮助？答案可能是心脏收缩。东北大学利用滚珠螺杆式电磁马达进行了“人造心肌”的开发研究。此外，目前正在尝试超小型化。因此，正在开发一种形状记忆合金系统。采用Peltier单元解决了冷却速度问题。通过该系统的应用，实现了心跳速度的驱动。目前，在日本，等待心脏移植的患者使用的是心脏辅助装置。空气驱动型系统连接到驱动装置，显著干扰了患者的生活质量。在我们的概念中，能量是通过经皮能量传输系统利用来自身体外部的电磁力来提供的。东北大学使用非晶态纤维进行磁屏蔽，以提高总效率。自然心脏可以根据需求改变心输出量。人工内脏也必须参与活体系统。东北大学开发了一种基于阻力的人工心脏控制算法，该算法模拟压力反射系统，以应对各种需求。东北大学目前正在开发纳米级传感设备。目前，正在进行的研发目标是“智能人造心肌”。
Where is the place which should be helped in a patient with congestive heart failure? The answer may be contraction of the heart. At Tohoku University, development research of ”the artificial myocardium” has been conducted, using a ball screw type electromagnetic motor. Furthermore, super-miniaturization is being attempted at present. Thus, a system with shape memory alloy is being developed. The cooling speed problem was solved by the application of the Peltier element. A drive at a speed equal to that of a heartbeat was realized by the application of this system. At present, a ventricular assist device is used for patients waiting for a heart transplant in Japan. An air driven type system disturbs a patient’s QOL remarkably because it is connected to the drive device. With our concept, energy is provided by using the electromagnetic force from outside of the body by the use of transcutaneous energy transmission system. Magnetic shielding by amorphous fibers was used at Tohoku University to improve the total efficiency. A natural heart can alter the cardiac output corresponding to the demand. Artificial internal organs must participate in the system of the living body, too. Tohoku University has developed a resistance based artificial heart control algorithm, which simulated a baroreflex system to cope with every demand. Nano level sensing equipment is now under development at Tohoku University. At present, development is being conducted aiming at an ”intelligent artificial myocardium”.