Post-traumatic stress disorder: a right temporal lobe syndrome?
Post-traumatic stress disorder: a right temporal lobe syndrome?
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DOI：
10.1088/1741-2560/7/6/066005
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发表时间：
2010-12-01
影响因子：
4
通讯作者：
Georgopoulos, A. P.
中科院分区：
文献类型：
--
作者：
Engdahl, B.;Leuthold, A. C.;Georgopoulos, A. P.
在最近的一篇论文中（Georgopoulos等2010 J Neural Eng 7 016011）我们报道了基于脑磁图（MEG）的同步神经相互作用（SNI）测试区分创伤后应激障碍（PTSD）的能力。从健康对照组的受试者，并以高度的准确性对他们进行分类。在这里，我们表明，这两个之间的皮层通信电路的主要差异这一偏侧化的颞-后沟通模式非常相似，但在PTSD缓解期患者中减弱。这些发现与观察结果一致。（Penfield 1958 Proc Natl Acad Sci USA 44 51-66，Penfield和Perot 1963 Brain 86 595-696，Gloor 1990 Brain 113 1673-94，Banceaud等1994 Brain 117 71-90 Fried 1997 J Neuropsycluatry Clin Neurosci 9 420-8），在清醒的人类受试者中颞叶皮层的电刺激主要在右半球，基于这些事实，我们将我们的发现归因于PTSD的再体验成分，并假设它反映了参与经验巩固的相互作用的神经网络的非自愿持续激活
In a recent paper (Georgopoulos et al 2010 J Neural Eng 7 016011) we reported on the power of the magnetoencephalography (MEG)-based synchronous neural interactions (SNI) test to differentiate post-traumatic stress disorder (PTSD) subjects from healthy control subjects and to classify them with a high degree of accuracy Here we show that the main differences in cortical communication circuitry between these two groups lie in the miscommunication of temporal and parietal and/or parieto-occipital right hemispheric areas with other brain areas This lateralized temporal-posterior pattern of miscommunication was very similar but was attenuated in patients with PTSD in remission These findings are consistent with observations (Penfield 1958 Proc Natl Acad Sci USA 44 51-66, Penfield and Perot 1963 Brain 86 595-696, Gloor 1990 Brain 113 1673-94, Banceaud et al 1994 Brain 117 71-90 Fried 1997 J Neuropsycluatry Clin Neurosci 9 420-8) that electrical stimulation of the temporal cortex m awake human subjects mostly in the right hemisphere, can elicit the re-enactment and re-living of past experiences Based on these facts, we attribute our findings to the re-experiencing component of PTSD and hypothesize that it reflects an involuntarily persistent activation of interacting neural networks involved in experiential consolidation