Fear conditioning induces associative long-term potentiation in the amygdala
Fear conditioning induces associative long-term potentiation in the amygdala
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DOI：
10.1038/37601
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发表时间：
1997-12-11
期刊：
影响因子：
64.8
通讯作者：
LeDoux, JE
中科院分区：
文献类型：
--
作者：
Rogan, MT;Staubli, UV;LeDoux, JE
长时程增强（LTP）是一种依赖于经验的神经可塑性形式，被认为涉及记忆形成的基础机制（1-3）。Lip在海马中的研究最为广泛，但海马Lip与记忆之间的关系一直难以建立（4-6）。在这里，我们探讨LTP和恐惧条件反射记忆之间的关系，杏仁核依赖的学习形式，其中无害的条件刺激（CS）eltered恐惧反应后，联想配对与厌恶的无条件刺激（US）。我们之前已经证明，在将听觉CS信息传递到杏仁核外侧核（LA）的通路中，唇诱导增加了该核的听觉诱发场电位（7）。现在，我们表明，恐惧条件反射改变听觉CS诱发的反应，在LA以同样的方式作为唇诱导，平行的变化收购CS引起的恐惧行为，是持久的，不发生，如果CS和US保持不配对。因此，LTP样的关联过程中发生的恐惧条件反射，这些可能是长期的关联可塑性，构成记忆的条件反射的经验。
Long-term potentiation (LTP) is an experience-dependent form of neural plasticity believed to involve mechanisms that underlie memory formation(1-3). Lip has been studied most extensively in the hippocampus, but the relation between hippocampal Lip and memory has been difficult to establish(4-6). Here we explore the relation between LTP and memory in fear conditioning, an amygdala-dependent form of learning in which an innocuous conditioned stimulus (CS) elicits fear responses after being associatively paired with an aversive unconditioned stimulus (US). We have previously shown that Lip induction in pathways that transmit auditory CS information to the lateral nucleus of the amygdala (LA) increases auditory-evoked field potentials in this nucleus(7). Now we show that fear conditioning alters auditory CS-evoked responses in LA in the same way as Lip induction, The changes parallel the acquisition of CS-elicited fear behaviour, are enduring, and do not occur if the CS and US remain unpaired. LTP-like associative processes thus occur during fear conditioning, and these may underlie the long-term associative plasticity that constitutes memory of the conditioning experience.