YKL-40--an emerging biomarker in cardiovascular disease and diabetes.
YKL-40--an emerging biomarker in cardiovascular disease and diabetes.
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DOI：
10.1186/1475-2840-8-61
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发表时间：
2009-11-23
影响因子：
9.3
通讯作者：
Vestergaard H
中科院分区：
文献类型：
--
作者：
Rathcke CN;Vestergaard H
几种炎性细胞因子参与导致内皮功能障碍的血管炎症，内皮功能障碍是导致明显心血管疾病的动脉粥样硬化过程中的最早事件。YKL-40是一种炎性糖蛋白，通过促进趋化性、细胞附着和迁移、重组和组织重塑作为对内皮损伤的响应而参与内皮功能障碍。YKL-40蛋白表达见于动脉粥样硬化斑块中的巨噬细胞和平滑肌细胞，其中在动脉粥样硬化早期病变中的巨噬细胞中表达最高。几项研究表明，血清YKL水平升高与冠状动脉疾病的存在和程度独立相关，并且在心肌梗死患者中记录了甚至更高的YKL-40水平。此外，还发现血清YKL-40水平升高与全因以及心血管死亡率相关。最后，与非糖尿病患者相比，1型和2型糖尿病患者的YKL-40水平均升高，已知1型和2型糖尿病患者处于心血管疾病发展的高风险中。在患有1型糖尿病的患者中已经描述了升高的循环YKL-40水平和升高的白蛋白尿水平之间的正相关性，表明YKL-40在导致微血管疾病的进行性血管损伤中的作用。本文综述了YKL-40的研究现状，讨论了其与内皮功能障碍、动脉粥样硬化、心血管疾病和糖尿病的关系，并对YKL-40的研究前景进行了展望。
Several inflammatory cytokines are involved in vascular inflammation resulting in endothelial dysfunction which is the earliest event in the atherosclerotic process leading to manifest cardiovascular disease. YKL-40 is an inflammatory glycoprotein involved in endothelial dysfunction by promoting chemotaxis, cell attachment and migration, reorganization and tissue remodelling as a response to endothelial damage. YKL-40 protein expression is seen in macrophages and smooth muscle cells in atherosclerotic plaques with the highest expression seen in macrophages in the early lesion of atherosclerosis. Several studies demonstrate, that elevated serum YKL-levels are independently associated with the presence and extent of coronary artery disease and even higher YKL-40 levels are documented in patients with myocardial infarction. Moreover, elevated serum YKL-40 levels have also been found to be associated with all-cause as well as cardiovascular mortality. Finally, YKL-40 levels are elevated both in patients with type 1 and type 2 diabetes, known to be at high risk for the development of cardiovascular diseases, when compared to non-diabetic persons. A positive association between elevated circulating YKL-40 levels and increasing levels of albuminuria have been described in patients with type 1 diabetes indicating a role of YKL-40 in the progressing vascular damage resulting in microvascular disease. This review describes the present knowledge about YKL-40 and discusses its relation to endothelial dysfunction, atherosclerosis, cardiovascular disease and diabetes and look ahead on future perspectives of YKL-40 research.
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影响因子：
4.1
作者：
Ling, H;Recklies, AD
通讯作者：
Recklies, AD
影响因子：
4.6
作者：
Johansen, J. S.;Pedersen, A. N.;Bruunsgaard, H.
通讯作者：
Bruunsgaard, H.
影响因子：
39.3
作者：
Kastrup, Jens;Johansen, Julia S.;Gluud, Christian
通讯作者：
Gluud, Christian
DOI：
10.1084/jem.20081271
发表时间：
2009-05-11
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Lee CG;Hartl D;Lee GR;Koller B;Matsuura H;Da Silva CA;Sohn MH;Cohn L;Homer RJ;Kozhich AA;Humbles A;Kearley J;Coyle A;Chupp G;Reed J;Flavell RA;Elias JA
通讯作者：
Elias JA
影响因子：
8.7
作者：
Boot, RG;van Achterberg, TAE;de Vries, CJM
通讯作者：
de Vries, CJM