Blood Urea Nitrogen/Creatinine Ratio Identifies a High-Risk but Potentially Reversible Form of Renal Dysfunction in Patients With Decompensated Heart Failure
Blood Urea Nitrogen/Creatinine Ratio Identifies a High-Risk but Potentially Reversible Form of Renal Dysfunction in Patients With Decompensated Heart Failure
复制标题
DOI：
10.1161/circheartfailure.112.968230
复制
发表时间：
2013-03-01
影响因子：
9.7
通讯作者：
Testani, Jeffrey M.
中科院分区：
文献类型：
--
作者：
Brisco, Meredith A.;Coca, Steven G.;Testani, Jeffrey M.
背景——识别心力衰竭情况下的可逆性肾功能障碍（RD）具有挑战性。本研究的目的是评估入院血尿素氮/肌酐比值 (BUN/Cr) 升高是否可以识别失代偿性心力衰竭患者，通过治疗可能会改善肾功能 (IRF)。 方法和结果——对出院诊断为心力衰竭的连续住院情况进行回顾。 IRF 定义为估计肾小球滤过率增加≥ 20%，肾功能恶化定义为估计肾小球滤过率降低≥ 20%。在 896 名符合资格标准的患者中，31% 发生 IRF。较高的入院 BUN/Cr 与住院 IRF 相关（比值比，每 10 次增加 1.5；95% 置信区间 [CI]，1.3-1.8；P
Background-Identifying reversible renal dysfunction (RD) in the setting of heart failure is challenging. The goal of this study was to evaluate whether elevated admission blood urea nitrogen/creatinine ratio (BUN/Cr) could identify decompensated heart failure patients likely to experience improvement in renal function (IRF) with treatment.Methods and Results-Consecutive hospitalizations with a discharge diagnosis of heart failure were reviewed. IRF was defined as >= 20% increase and worsening renal function as >= 20% decrease in estimated glomerular filtration rate. IRF occurred in 31% of the 896 patients meeting eligibility criteria. Higher admission BUN/Cr was associated with inhospital IRF (odds ratio, 1.5 per 10 increase; 95% confidence interval [CI], 1.3-1.8; P